The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen
The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen
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DOI：
10.1093/humrep/13.11.3000
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发表时间：
1998-11-01
影响因子：
6.1
通讯作者：
Lewis-Jones, DI
中科院分区：
文献类型：
--
作者：
Manning, JT;Scutt, D;Lewis-Jones, DI
脊椎动物的泌尿生殖系统和尾骨的分化受Hox基因的控制。手指和性腺分化的共同控制提出了手指形成模式可能与精子发生和激素浓度有关的可能性。这项工作是关于人类第二和第四手指（2D:4D）长度之间的比例。我们发现：(1)左手和右手的2D:4D具有两性二态模式；男性平均2D:4D = 0.98，即第4根手指比第2根手指长；女性平均2D:4D = 1.00，即第2根和第4根手指长度相等。二态性至少从2岁开始存在，2D:4D可能是在子宫内建立的；（ii）男性右手2D:4D比值高与生殖细胞衰竭相关（P = 0.04）；（iii）右手精子数与2D:4D呈负相关（P = 0.004）；（iv）男性睾酮浓度与右手2D:4D呈负相关，女性和男性LH（右手）、雌激素（右手和左手）、催乳素（右手）浓度与2D:4D呈正相关；(v)在控制性别、年龄、身高、体重后，右手2D:4D与黄体生成素、雌激素呈正相关。
The differentiation of the urinogenital system and the appendicular skeleton in vertebrates is under the control of Hox genes. The common control of digit and gonad differentiation raises the possibility that patterns of digit formation may relate to spermatogenesis and hormonal concentrations. This work was concerned with the ratio between the length of the 2nd and 4th digit (2D:4D) in humans. We showed that (i) 2D:4D in right and left hands has a sexually dimorphic pattern; in males mean 2D:4D = 0.98, i.e. the 4th digit tended to be longer than the 2nd and in females mean 2D:4D = 1.00, i.e. the 2nd and 4th digits tended to be of equal length. The dimorphism is present from at least age 2 years and 2D:4D is probably established in utero; (ii) high 2D:4D ratio in right hands was associated with germ cell failure in men (P = 0.04); (iii) sperm number was negatively related to 2D:4D in the right hand (P = 0.004); (iv) in men testosterone concentrations were negatively related to right hand 2D:4D and in women and men LH (right hand), oestrogen (right and left hands) and prolactin (right hand) concentrations were positively correlated with 2D:4D ratio and (v) 2D:4D ratio in right hands remained positively related to luteinizing hormone and oestrogen after controlling for sex, age, height and weight.