Δ9-Tetrahydrocannabinol stimulation of estrogen receptor-positive MCF-7 breast cancer cell migration: Interfering interaction with the estrogenic milieu
Δ9-Tetrahydrocannabinol stimulation of estrogen receptor-positive MCF-7 breast cancer cell migration: Interfering interaction with the estrogenic milieu
复制标题
Δ9-四氢大麻酚刺激雌激素受体阳性 MCF-7 乳腺癌细胞迁移：干扰与雌激素环境的相互作用
DOI：
10.1007/s11419-022-00655-5
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发表时间：
2022
影响因子：
2.2
通讯作者：
Watanabe Kazuhito
中科院分区：
文献类型：
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作者：
Takeda Shuso;Hirao-Suzuki Masayo;Aramaki Hironori;Watanabe Kazuhito
目的研究Δ9-四氢大麻酚（Δ9-THC）长时间暴露对雌激素受体阳性的人乳腺癌MCF-7细胞的影响，但Δ9-THC短时间暴露的影响尚不清楚。在这项研究中，我们试图研究Δ9-THC是否刺激MCF-7细胞在雌激素和雌激素剥夺条件下的迁移方法MCF-7细胞在雌激素或雌激素剥夺条件下用Δ9-THC处理，结果Δ9-THC刺激的MCF-7细胞迁移仅在雌激素刺激的MCF-7细胞中观察到。剥夺的条件。结论Δ 9-THC可刺激MCF-7细胞在雌激素缺乏条件下的迁移，但Δ9-THC与雌激素环境之间存在干扰作用，影响MCF-7细胞的迁移。
PurposeThe effects of extended Δ9-tetrahydrocannabinol (Δ9-THC) exposure on estrogen receptor-positive human breast cancer MCF-7 cells have been investigated; however, the effects of Δ9-THC exposure for a shorter duration remain unclear. In this study, we sought to study whether Δ9-THC stimulates the migration of MCF-7 cells under both estrogenic and estrogen-deprived conditions over a short period (approximately 6 h).MethodsMCF-7 cells were treated with Δ9-THC under estrogenic or estrogen-deprived conditions, and cell migration was subsequently analyzed.ResultsΔ9-THC-stimulated migration of MCF-7 cells 6 h after exposure was only observed in the estrogen-deprived condition. However, Δ9-THC-mediated migration was counteracted under estrogenic conditions without affecting cell proliferation and estrogen receptor expression during this period.ConclusionsΔ9-THC can stimulate MCF-7 cell migration under estrogen-deprived conditions; however, there is an interfering interaction between Δ9-THC and the estrogenic milieu that influences the migration of MCF-7 cells.