Prenatal influences on stroke mortality in England and Wales

Prenatal influences on stroke mortality in England and Wales
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DOI：
10.1161/01.str.0000077257.27430.7e
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发表时间：
2003-07-01
期刊：
STROKE
影响因子：
8.3
通讯作者：
Lackland, DT
Lackland, DT
中科院分区：
医学1区
文献类型：
--
作者：
Barker, DJP;Lackland, DT

文献摘要

被引文献

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背景和目的——在英国和美国，中风死亡率存在地域差异，这不能用成人生活方式的差异来解释。我们报告了英格兰和威尔士中风死亡率的地理分布，并将其与美国进行比较。方法——提供了 4 项研究的数据。将 1968-1978 年英格兰和威尔士脑卒中死亡的地理分布与以下分布进行比较：(1) 同年其他死因、(2) 1911-1925 年新生儿和孕产妇死亡率、(3) 成人平均身高和 (4) 出生地。 结果 - 英格兰和威尔士脑卒中死亡率高的地区过去的特点是生活水平差，婴儿和孕产妇死亡率高就证明了这一点 和成年人身材矮小。出生在中风死亡率高的地区而不是移民到这些地区的人面临高风险。卒中死亡率与过去的新生儿死亡率在地理上不相关，独立于新生儿或孕产妇死亡率。美国、英格兰和威尔士的中风死亡率的地理分布具有共同特征。结论：中风可能源于与贫困相关的母亲影响。最近的研究结果支持了这一结论，即低出生体重的人成年后中风的发生率较高。
Background and Purpose-Within Britain and the United States there are geographic variations in mortality from stroke that are not explained by differences in adult lifestyle. We report on the geographic distribution of stroke mortality in England and Wales and compare it with that in the United States.Methods-Data from 4 studies are presented. The geographic distribution of stroke deaths in England and Wales during 1968-1978 is compared with the distribution of (1) other causes of death during the same years, (2) neonatal and maternal mortality during 1911-1925, (3) average adult height, and (4) place of birth.Results-Areas of England and Wales with high stroke mortality were characterized in the past by poor living standards, demonstrated by high infant and maternal mortality rates and short stature in the adult population. People who were born in areas of high stroke mortality rather than migrating into them are at high risk. Stroke mortality is not geographically correlated with past postneonatal mortality independently of neonatal or maternal mortality. The geographic distribution of stroke mortality in the United States and England and Wales has features in common.Conclusions-Stroke may originate through maternal influences associated with poverty. This conclusion is supported by recent findings that rates of stroke in adult life are higher among people who had low birth weight.