Heavy Metals and Cardiovascular Disease: Results from the National Health and Nutrition Examination Survey (NHANES) 1999-2006
Heavy Metals and Cardiovascular Disease: Results from the National Health and Nutrition Examination Survey (NHANES) 1999-2006
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DOI：
10.1177/0003319710395562
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发表时间：
2011-07-01
期刊：
影响因子：
2.8
通讯作者：
Kapadia, Samir R.
中科院分区：
文献类型：
--
作者：
Agarwal, Shikhar;Zaman, Tarique;Kapadia, Samir R.
我们评估了铅和镉作为吸烟与复合性心脑血管疾病（CCVD）之间部分介质的作用。我们还研究了尿中重金属与CCVD的关系。对1999-2006年NHANES的汇总数据进行了检查。心血管和脑血管疾病的确定使用标准化问卷调查，询问中风，心绞痛，心脏病发作，冠状动脉疾病和充血性心力衰竭的历史。血清镉水平升高与CCVD患病率升高相关（P趋势：0.03）。主动吸烟者与从不吸烟者的校正比值比（OR）为2.09（1.67-2.63）。铅校正不影响OR，但镉校正显著降低OR（1.54 [1.17-2.03]）。CCVD与尿锑、镉、钴和钨显著相关。高血清镉水平（>0.61 μ g/L）与CCVD有关。吸烟与CCVD的关系部分通过镉介导。尿锑、镉、钴和钨可能与CCVD有关。
We assessed the role of lead and cadmium as partial mediators between smoking and composite cardiovascular and cerebrovascular disease (CCVD). We also studied the association between urinary heavy metals and CCVD. Pooled data from NHANES 1999-2006 were examined. Cardiovascular and cerebrovascular disease was determined using a standardized questionnaire asking about history of stroke, angina, heart attack, coronary artery disease, and congestive heart failure. Increasing serum cadmium levels were associated with increasing prevalence of CCVD (P-trend: .03). Adjusted odds-ratio (OR) for active smokers versus never smokers was 2.09 (1.67-2.63). Adjustment for lead did not affect the OR but adjustment for cadmium significantly attenuated the OR (1.54 [1.17-2.03]). Significant association was observed between CCVD and urinary antimony, cadmium, cobalt, and tungsten. High levels of serum cadmium (>0.61 mu g/L) were associated with CCVD. The relationship between smoking and CCVD was partially mediated through cadmium. Urinary antimony, cadmium, cobalt, and tungsten may be associated with CCVD.