Effects of different nicotine replacement therapies on postcessation psychological responses.
Effects of different nicotine replacement therapies on postcessation psychological responses.
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不同尼古丁替代疗法对戒烟后心理反应的影响。
DOI：
10.1016/j.addbeh.2004.04.005
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发表时间：
2005
影响因子：
4.4
通讯作者：
Lerman,Caryn
中科院分区：
文献类型：
--
作者：
Strasser,AndrewA;Kaufmann,Vyga;Jepson,Christopher;Perkins,KennethA;Pickworth,WallaceB;Wileyto,EPaul;Rukstalis,Margaret;Audrain-McGovern,Janet;Lerman,Caryn
经皮尼古丁贴片（TN）和尼古丁鼻喷雾剂（NS）都是有效的戒烟治疗形式，但具有不同的药代动力学特性和作用模式。为了更好地了解治疗的心理反应，我们研究了TN与NS在治疗期间对积极情感，消极情感和戒断症状的影响。参与者被随机分配到接受TN（n=172）或NS（n=163）加7个疗程的行为咨询，并在治疗前和治疗期间完成自我报告问卷。TN参与者，而不是NS参与者，在治疗期间报告了积极影响的显着增加。观察到负面影响和戒断增加，与治疗无关。只有负面情绪的变化才能预测治疗期结束时的复发。这些研究结果表明，虽然TN可能会提高积极的影响，吸烟者在治疗中相比NS，只有负面影响的变化预测治疗结果。
Transdermal nicotine patch (TN) and nicotine nasal spray (NS) are both efficacious forms of smoking cessation treatment, but have different pharmacokinetic properties and modes of action. To understand better psychological responses to treatment, we investigated the effects of TN versus NS on positive affect, negative affect, and withdrawal symptoms during treatment. Participants were randomly assigned to receive TN (n=172) or NS (n=163) plus seven sessions of behavioral counseling, and completed self-report questionnaires at pretreatment and during treatment. TN participants, but not NS participants, reported significant increases in positive affect during treatment. Increases in negative affect and withdrawal were observed, independent of treatment. Only changes in negative affect predicted relapse by the end of the treatment phase. These findings indicate that, although TN may enhance positive affect for smokers in treatment compared with NS, only changes in negative affect predict treatment outcome.