Neighbourhoods matter too: the association between neighbourhood socioeconomic position, population density and breast, prostate and lung cancer incidence in Denmark between 2004 and 2008
Neighbourhoods matter too: the association between neighbourhood socioeconomic position, population density and breast, prostate and lung cancer incidence in Denmark between 2004 and 2008
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DOI：
10.1136/jech-2011-200192
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发表时间：
2013-01-01
影响因子：
6.3
通讯作者：
Engholm, Gerda
中科院分区：
文献类型：
--
作者：
Meijer, Mathias;Bloomfield, Kim;Engholm, Gerda
研究背景以往的研究表明，癌症的发病率与许多个体因素有关，包括社会经济地位。本研究的目的是通过评估社区特征对丹麦乳腺癌、前列腺癌和肺癌发病率的影响来完善目前关于癌症发病率相关指标的知识。对50至83岁的男性进行前列腺癌随访，对50至83岁的男女进行肺癌随访。从丹麦统计局获得的登记数据包括年龄、性别、乳腺癌筛查的可用性、婚姻状况、教育、个人可支配收入和职业社会经济地位，以及教区一级的人口密度和社区社会经济地位（失业者比例）。第一级的个人和教区的第二级的脆弱modeling carried.Results乳腺癌的显着降低HR被发现在人口密度低的地区（HR=0.93; CI 0.88至0.99），而邻里失业没有影响。与高失业率地区的居民相比，低失业率地区的居民患前列腺癌的风险更高（HR=1.14; CI 1.08至1.21），而人口密度没有影响。肺癌的风险较低的地区，人口密度最低（HR=0.80; CI 0.74至0.85）和最低的地区，失业率最低（HR=0.88; CI 0.84至0.92）。结论除了个人层面的因素，在邻里水平的特点也有影响乳腺癌，前列腺癌和肺癌的发病率。
Background Previous studies have shown that cancer incidence is related to a number of individual factors, including socioeconomic status. The aim of this study was to refine the current knowledge about indicators associated with cancer incidence by evaluating the influence of neighbourhood characteristics on breast, prostate and lung cancer incidence in Denmark.Methods All women aged 30-83 years were followed for breast cancer between 2004 and 2008, men between 50 and 83 years were followed for prostate cancer and both sexes between ages 50 and 83 were followed for lung cancer. Registry data obtained from Statistics Denmark included age, sex, availability of breast cancer screening, marital status, education, disposable income and occupational socioeconomic status on the individual level and population density and neighbourhood socioeconomic status (the proportion of unemployed) on the parish level. Frailty modelling with individuals on the first level and parishes on the second level was conducted.Results A significantly lower HR of breast cancer was found in areas with low population density (HR=0.93; CI 0.88 to 0.99), while neighbourhood unemployment had no effect. Inhabitants of lower unemployment areas had a higher risk of prostate cancer (HR=1.14; CI 1.08 to 1.21) compared with those in higher unemployment areas, whereas population density had no effect. Risk of lung cancer was lower in areas with lowest population density (HR=0.80; CI 0.74 to 0.85) and lowest in areas with lowest unemployment (HR=0.88; CI 0.84 to 0.92).Conclusions In addition to individual-level factors, characteristics on the neighbourhood level also have an influence on breast, prostate and lung cancer incidence.