The First Syntheses of (±)-SDEF 678 Metabolite and (±)-Speciosins A-C
The First Syntheses of (±)-SDEF 678 Metabolite and (±)-Speciosins A-C
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(±)-SDEF 678 代谢物和 (±)-Speciosins A-C 的首次合成
DOI：
10.1002/ejoc.201001402
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发表时间：
2010
影响因子：
2.8
通讯作者：
Hookins D
中科院分区：
文献类型：
--
作者：
Hookins D
通过钯催化的卤素取代1,4 -苯醌单酮偶联、Diels-Alder /retro - Diels-Alder序列和非对映选择性环氧化反应，首次制备了环氧醌天然产物SDEF 678代谢物speciosin A、speciosin B和speciosin C。
The epoxyquinone natural products SDEF 678 metabolite, speciosin A, speciosin B and speciosin C have been prepared for the first time via a short synthetic route based around the palladium‐catalysed coupling of a halogen‐substituted 1,4‐benzoquinone monoketal, a Diels–Alder/retro‐Diels–Alder sequence and a diastereoselective epoxidation process.