Minimal model of a cell connecting amoebic motion and adaptive transport networks
Minimal model of a cell connecting amoebic motion and adaptive transport networks
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DOI：
10.1016/j.jtbi.2008.04.017
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发表时间：
2008-08-21
影响因子：
2
通讯作者：
Haruna, Taichi
中科院分区：
文献类型：
--
作者：
Gunji, Yukio-Pegio;Shirakawa, Tomohiro;Haruna, Taichi
细胞是一个最小的自我维持的系统，可以移动和计算。以前的工作表明，单细胞粘菌--绒泡菌--可以用作基于膜包裹的细胞质流动的生物计算机。虽然细胞边界的改变和被边界包围的细胞质流动之间的相互作用在绒泡菌的计算中起着关键作用，但还没有细胞模型来描述这种相互作用。在这里，我们提出了一个细胞的玩具模型，它显示了阿米巴运动，并可以解决迷宫、Steiner最小树问题和生成树问题。只有假设细胞质在外部物质(或软化部分)通过细胞后变硬，细胞的形状和细胞质的流动才能改变。没有细胞质的硬化，细胞很容易被破坏。这表明，由外界扰动引起的细胞质硬化和/或溶胶-凝胶转变可以使细胞保持在临界状态，从而导致各种形状和运动。(C)2008爱思唯尔有限公司。保留所有权利。
A cell is a minimal self-sustaining system that can move and compute. Previous work has shown that a unicellular slime mold, Physarum, can be utilized as a biological computer based on cytoplasmic flow encapsulated by a membrane. Although the interplay between the modification of the boundary of a cell and the cytoplasmic flow surrounded by the boundary plays a key role in Physarum computing, no model of a cell has been developed to describe this interplay. Here we propose a toy model of a cell that shows amoebic motion and can solve a maze, Steiner minimum tree problem and a spanning tree problem. Only by assuming that cytoplasm is hardened after passing external matter (or softened part) through a cell, the shape of the cell and the cytoplasmic flow can be changed. Without cytoplasm hardening, a cell is easily destroyed. This suggests that cytoplasmic hardening and/or sol-gel transformation caused by external perturbation can keep a cell in a critical state leading to a wide variety of shapes and motion. (C) 2008 Elsevier Ltd. All rights reserved.