Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma
Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma
复制标题
DOI：
10.3109/00016489.2014.920962
复制
发表时间：
2014-09-01
影响因子：
1.4
通讯作者：
Duan, Maoli
中科院分区：
文献类型：
--
作者：
Gao, Chaobing;Li, Xiaohong;Duan, Maoli
结论：Dicer蛋白的高表达可能是喉鳞状细胞癌（LSCC）患者预后的一个生物标志物。目的：近年来的研究表明，多种microRNAs（miRNAs）在人类肿瘤的发生、发展中起着重要作用。Dicer是miRNA机制中最重要的酶之一，负责miRNA生物合成的最后一步。本研究旨在研究Dicer表达对人喉鳞状细胞癌患者生存率的影响。方法：采用免疫组织化学方法检测76例喉鳞癌组织和26例喉息肉组织中Dicer蛋白的表达。探讨Dicer蛋白在喉鳞癌中的表达及其与临床病理和预后的关系。结果：Dicer在喉鳞状细胞癌中的表达明显高于在息肉组织中的表达。Dicer表达水平与pTNM分期、淋巴结转移密切相关。Kaplan-Meier生存分析显示肿瘤Dicer表达与LSCC患者的生存之间存在强相关性。
Conclusions: Increased expression of Dicer may be a prognostic biomarker for patients with laryngeal squamous cell carcinoma (LSCC). Objectives: Recent studies have shown that many microRNAs (miRNAs) play an important role in the development and progression of human cancers. Dicer, one of the most important enzymes of the miRNA machinery, performs the final step of biogenesis of miRNAs. This study aimed to investigate the impact of Dicer expression on patient survival in human LSCC. Methods: We detected the expression of Dicer in larynx tissue specimens from 76 LSCC samples and 26 polyps by immunohistochemistry. The clinicopathological and prognostic significance of Dicer expression was investigated in LSCC. Results: Our data showed that the expression of Dicer was significantly higher in the LSCC than in the polyp tissue specimens. Moreover, the expression level of Dicer was significantly associated with the pTNM stage and tumor lymph node metastasis. Kaplan-Meier survival analyses revealed a strong association between tumor Dicer expression and the survival of the patients with LSCC.