MitoDrome:: a database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion
MitoDrome:: a database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion
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DOI：
10.1093/nar/gkg123
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Caggese, C
中科院分区：
文献类型：
--
作者：
Sardiello, M;Licciulli, F;Caggese, C
线粒体是存在于大多数真核细胞细胞质中的细胞器；虽然它们有自己的DNA，但功能线粒体所需的大部分蛋白质是由核DNA编码的，只有经过转录和翻译后，它们才能作为蛋白质输入线粒体。线粒体的主要作用是电子传递和氧化磷酸化。虽然研究线粒体已经很长时间了，但由于线粒体在细胞凋亡、衰老和癌症中的作用的发现，研究人员对线粒体的兴趣仍然存在。MitoDrome数据库的目的是注释编码线粒体蛋白的黑胃果蝇核基因，以有助于线粒体蛋白编码核基因的功能表征和线粒体功能障碍相关的基因疾病的知识。事实上，黑腹龙是研究最多的生物之一，也是人类基因组的模型。数据来源于人类线粒体蛋白与果蝇基因组、ESTs和cDNA序列数据在FlyBase数据库中的比较。从MitoDrome条目到MitoNuC中可用的相关同源条目的链接将很快实现。MitoDrome数据库可在http://bighost.area.ba.cnr.it/BIG/MitoDrome上获得。数据以平面文件格式组织，可以使用SRS系统检索。
Mitochondria are organelle present in the cytoplasm of most eukaryotic cells; although they have their own DNA, the majority of the proteins necessary for a functional mitochondrion are coded by the nuclear DNA and only after transcription and translation they are imported in the mitochondrion as proteins. The primary role of the mitochondrion is electron transport and oxidative phosphorylation. Although it has been studied for a long time, the interest of researchers in mitochondria is still alive thank to the discovery of mitochondrial role in apoptosis, aging and cancer. Aim of the MitoDrome database is to annotate the Drosophila melanogaster nuclear genes coding for mitochondrial proteins in order to contribute to the functional characterization of nuclear genes coding for mitochondrial proteins and to knowledge of gene disease related to mitochondrial dysfunctions. Indeed D. melanogaster is one of the most studied organism and a model for the Human genome. Data are derived from the comparison of Human mitochondrial proteins versus the Drosophila genome, ESTs and cDNA sequence data available in the FlyBase database. Links from the MitoDrome entries to the related homologous entries available in MitoNuC will be soon implemented. The MitoDrome database is available at http://bighost.area.ba.cnr.it/BIG/MitoDrome. Data are organised in a flat-file format and can be retrieved using the SRS system.