22 week assessment of bladder acellular matrix as a bladder augmentation material in a porcine model
22 week assessment of bladder acellular matrix as a bladder augmentation material in a porcine model
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DOI：
10.1016/s0142-9612(01)00350-7
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发表时间：
2002-05-01
期刊：
影响因子：
14
通讯作者：
Woodhouse, KA
中科院分区：
文献类型：
--
作者：
Brown, AL;Farhat, W;Woodhouse, KA
前人对异体膀胱脱细胞基质移植(BAMA)重建猪膀胱的研究表明，在移植物收缩和细胞再生方面取得了积极的初步结果。目前的研究是为了探讨在类似的膀胱重建模型中使用BAMA的可行性，以延长时间框架(22周)。在预定的时间点，对移植的天然和巴马组织的宏观、组织学和力学性能进行评估和比较。肉眼可见BAMA肌挛缩。移植物的周边区域经历了广泛的细胞再生。然而，在中央，所有移植物始终缺乏有组织的平滑肌束和发育良好的尿路上皮。在这个区域内，还观察到胶原的数量和组织的变化。显著差异(p
Previous studies on the reconstruction of porcine bladder using bladder acellular matrix allograft (BAMA) have indicated positive preliminary results with respect to graft shrinkage and cellular repopulation. The current study was conducted to investigate the feasibility of using BAMA in a similar model of bladder reconstruction out to longer time frames (22 weeks). At predetermined time points, the macroscopic, histological and mechanical properties of explanted native and BAMA tissues were evaluated and compared. Macroscopically, contracture of the BAMA was observed. The peripheral regions of the grafts experienced extensive cellular repopulation. Towards the centre however, all grafts were consistently devoid of organized smooth muscle bundles and a well-developed urothelium. An alteration in both the amount and organization of collagen was also observed within this region. Significant differences (p