Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides
Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides
复制标题
新型咪唑类融合喹诺酮羧酰胺的设计、合成、结构-活性关系和抗菌活性系列
DOI：
10.1016/j.ejmech.2008.07.024
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发表时间：
2009-04-01
影响因子：
6.7
通讯作者：
Parthasarathy, T.
中科院分区：
文献类型：
--
作者：
Reddy, G. Venkat;Kanth, S. Ravi;Parthasarathy, T.
合成了一系列新的7，8和1，8咪唑并喹诺酮酰胺类化合物，并对其抗菌活性进行了评价。1，8-咪唑并喹诺酮类化合物具有一定的抗菌活性。进行分子模拟研究以优化药效团。[图片]（C）2008 Elsevier Masson SAS. All rights reserved.
A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore.[GRAPHICS](C) 2008 Elsevier Masson SAS. All rights reserved.