Gating of Acoustic Transducer Channels Is Shaped by Biomechanical Filter Processes
Gating of Acoustic Transducer Channels Is Shaped by Biomechanical Filter Processes
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DOI：
10.1523/jneurosci.3948-15.2016
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发表时间：
2016-02-24
影响因子：
5.3
通讯作者：
Nowotny, Manuela
中科院分区：
文献类型：
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作者：
Hummel, Jennifer;Schoeneich, Stefan;Nowotny, Manuela
声信号的机电转导是整个动物王国中所有耳朵的听觉的基本过程。在这里，我们在昆虫耳朵（Mecopoda elongata）的转导部位进行了体内激光振动测量和电生理测量，以将听觉器官的生物力学张力toptoption与相应感觉细胞的频率调谐联系起来。我们的机械和电生理图谱揭示了一个生物力学过滤过程，大大增强了神经元的反应。我们证明，通道门控，其作用于声带拉伸受体神经元，是基于机械方向的声音诱导运动。此外，对转导部位的解剖学研究支持了我们的发现，即刺激相关的倾斜。总之，我们能够证明，在昆虫的耳朵中，通道门控的方向性在外周水平上显著地增强了神经元的频率选择性，并确定了一种在tonotopically组织的耳朵中增强频率辨别的机制。
Mechanoelectrical transduction of acoustic signals is the fundamental process for hearing in all ears across the animal kingdom. Here, we performed in vivo laser-vibrometric and electrophysiological measurements at the transduction site in an insect ear (Mecopoda elongata) to relate the biomechanical tonotopy along the hearing organ to the frequency tuning of the corresponding sensory cells. Our mechanical and electrophysiological map revealed a biomechanical filter process that considerably sharpens the neuronal response. We demonstrate that the channel gating, which acts on chordotonal stretch receptor neurons, is based on a mechanical directionality of the sound-induced motion. Further, anatomical studies of the transduction site support our finding of a stimulus-relevant tilt. In conclusion, we were able to show, in an insect ear, that directionality of channel gating considerably sharpens the neuronal frequency selectivity at the peripheral level and have identified a mechanism that enhances frequency discrimination in tonotopically organized ears.