Future Perspectives in Bladder Tissue Engineering.
Future Perspectives in Bladder Tissue Engineering.
复制标题
膀胱组织工程的未来观点。
DOI：
10.1007/s11884-015-0327-2
复制
发表时间：
2014-12-01
影响因子：
0.4
通讯作者：
Chermansky CJ
中科院分区：
文献类型：
--
作者：
Gill BC;Damaser MS;Chermansky CJ
大量的临床需求持续存在，改良的自体组织来增加或替代膀胱，研究已经开始使用组织工程技术来解决这个问题。允许天然膀胱组织向内生长的组织支架的植入和由这种支架的体外细胞化产生的自体膀胱移植物的植入已经进行了临床测试；然而，两种情况下的成功结果都受到移植物大尺寸导致的血管不足的挑战，这随后限制了组织向内生长并导致移植物缺血。因此，最近的研究集中在开发更好的方法来生产增加组织长入和血管的支架。这篇综述提供了膀胱组织工程的最新进展，并概述了临床实施中仍然存在的挑战。
Substantial clinical need persists for improved autologous tissues to augment or replace the urinary bladder and research has begun to address this using tissue engineering techniques. The implantation of both tissue scaffolds which allow for native bladder tissue ingrowth and autologous bladder grafts created from in vitro cellularization of such scaffolds have been tested clinically; however, successful outcomes in both scenarios have been challenged by insufficient vascularity resulting from large graft sizes, which subsequently limits tissue ingrowth and leads to central graft ischemia. Consequently, recent research has focused on developing better methods to produce scaffolds with increased tissue ingrowth and vascularity. This review provides an update on bladder tissue engineering and outlines the challenges that remain to clinical implementation.