Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients.
Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients.
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用于预测 TNBC 患者治疗前 CA15-3 和 CEA 血清水平预后价值的列线图
DOI：
10.1371/journal.pone.0161902
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Wei W
中科院分区：
文献类型：
--
作者：
Dai D;Chen B;Tang H;Wang B;Zhao Z;Xie X;Wei W
以往的研究表明，癌胚抗原（CEA）和癌抗原15-3（CA 15 -3）水平都是乳腺癌的独立预后因素。然而，CEA和CA 15 -3水平作为三阴性乳腺癌（TNBC）患者的常规癌症生物标志物的效用仍然存在争议。进行本研究以探索治疗前血清CEA和CA 15 -3水平的预测价值，并开发包括这些血清癌症生物标志物的列线图以改善TNBC患者的预后评估。在247例I-IV期TNBC患者中测量治疗前CA 15 -3和CEA浓度。Kaplan-Meier分析显示CEA和CA 15 -3均高水平的TNBC患者的总生存率（OS）和无病生存率（DFS）均低于低水平组（p<0.05）。多变量分析表明，治疗前CA 15 -3和CEA水平是OS（分别为p = 0.022和p = 0.040）和DFS（分别为p = 0.023和p = 0.028）的独立预测因素。此外，建立并验证了新的列线图，以提供TNBC患者的OS和DFS的个人预测。这些新的列线图可以帮助医生选择最佳的治疗计划，以确保TNBC患者的最佳结果。
Previous studies have indicated that carcinoembryonic antigen (CEA) and cancer antigen 15–3 (CA15-3) levels are both independent prognostic factors in breast cancer. However, the utility of CEA and CA15-3 levels as conventional cancer biomarkers in patients with triple-negative breast cancer (TNBC) remains controversial. The current study was performed to explore the predictive value of pre-therapeutic serum CEA and CA15-3 levels, and nomograms were developed including these serum cancer biomarkers to improve the prognostic evaluation of TNBC patients. Pre-therapeutic CA15-3 and CEA concentrations were measured in 247 patients with stage I–IV TNBC. Kaplan-Meier analysis showed that TNBC patients with high levels of both CEA and CA15-3 had shorter overall survival (OS) and disease-free survival (DFS) rates than those in the low-level groups (p<0.05). Multivariate analysis suggested that pre-therapeutic CA15-3 and CEA levels are independent predictive elements for OS (p = 0.022 and p = 0.040, respectively) and DFS (p = 0.023 and p = 0.028, respectively). In addition, novel nomograms were established and validated to provide personal forecasts of OS and DFS for patients with TNBC. These novel nomograms may help physicians to select the optimal treatment plans to ensure the best outcomes for TNBC patients.
影响因子：
8.8
作者：
Robertson, J. F. R.;Whynes, D. K.;Dixon, A.;Blamey, R. W.
通讯作者：
Blamey, R. W.