Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15).
Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15).
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DOI：
10.1016/j.gene.2015.07.073
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发表时间：
2015-11-15
期刊：
影响因子：
3.5
通讯作者：
Heydeck D
中科院分区：
文献类型：
--
作者：
Ivanov I;Kuhn H;Heydeck D
脂氧合酶（LOX）是一个脂质过氧化酶家族，参与多种生理过程，并参与炎症、过度增殖和神经退行性疾病的发病机制。它们出现在陆地生命的三个领域中的两个（细菌，真核生物），人类基因组涉及六个功能性LOX基因，其编码六种不同的LOX亚型。这些亚型之一是ALOX 15，其于1974年首次在兔中被描述为能够在未成熟红细胞中线粒体的成熟分解期间氧化膜磷脂的酶。在随后的几十年中，ALOX 15已被广泛表征，并且已在许多细胞体外系统以及各种完整动物疾病模型中研究了其生物学功能。本文综述了ALOX15在不同物种（人、小鼠、兔、大鼠）中的蛋白质化学、分子生物学和酶学性质及其在细胞生理学和各种疾病发病机制中的意义。
Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes, which have been implicated in a number of physiological processes and in the pathogenesis of inflammatory, hyperproliferative and neurodegenerative diseases. They occur in two of the three domains of terrestrial life (bacteria, eucarya) and the human genome involves six functional LOX genes, which encode for six different LOX isoforms. One of these isoforms is ALOX15, which has first been described in rabbits in 1974 as enzyme capable of oxidizing membrane phospholipids during the maturational breakdown of mitochondria in immature red blood cells. During the following decades ALOX15 has extensively been characterized and its biological functions have been studied in a number of cellular in vitro systems as well as in various whole animal disease models. This review is aimed at summarizing the current knowledge on the protein-chemical, molecular biological and enzymatic properties of ALOX15 in various species (human, mouse, rabbit, rat) as well as its implication in cellular physiology and in the pathogenesis of various diseases.
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影响因子：
3.9
作者：
Adel, Susan;Kakularam, Kumar Reddy;Heydeck, Dagmar
通讯作者：
Heydeck, Dagmar
DOI：
10.1111/j.1742-1241.2007.01320.x
发表时间：
2007-04-01
影响因子：
2.6
作者：
Berger, W.;De Chandt, M. T. M.;Cairns, C. B.
通讯作者：
Cairns, C. B.
影响因子：
4.1
作者：
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通讯作者：
Habenicht, AJR
DOI：
10.1016/j.bbalip.2014.07.005
发表时间：
2014-10-01
影响因子：
4.8
作者：
Adel, Susan;Hofheinz, Katharina;Haefner, Ann-Kathrin
通讯作者：
Haefner, Ann-Kathrin
DOI：
10.1111/j.1432-1033.1993.tb17755.x
发表时间：
1993-04-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
BELKNER, J;WIESNER, R;KUHN, H
通讯作者：
KUHN, H