Perivascular spaces on 7 Tesla brain MRI are related to markers of small vessel disease but not to age or cardiovascular risk factors
Perivascular spaces on 7 Tesla brain MRI are related to markers of small vessel disease but not to age or cardiovascular risk factors
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DOI：
10.1177/0271678x16648970
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发表时间：
2016-10-01
影响因子：
6.3
通讯作者：
Biessels, Geert Jan
中科院分区：
文献类型：
--
作者：
Bouvy, Willem H.;Zwanenburg, Jaco J. M.;Biessels, Geert Jan
脑血管周围间隙（PVS）是大脑血管周围的小生理结构。MRI可见PVS与衰老和脑血管疾病（SVD）相关。7特斯拉（7T） MRI改善了PVS检测。我们研究了年龄、血管危险因素和SVD成像标志物与50例40岁患者的7t MRI PVS计数的关系。右半球PVS +/- SD平均计数基底节区为17 +/- 6，半中枢区为71 +/- 28。我们观察到年龄或血管危险因素与PVS计数没有关系。微出血的存在与基底节区更多的PVS（标准化β 0.32, p = 0.04）和半隔中心（标准化β 0.39, p = 0.01）有关，白质高强度体积与基底节区更多的PVS有关（标准化β 0.41, p = 0.02）。我们得出结论，7T MRI上的PVS计数高，与SVD标志物相关，但与年龄和血管危险因素无关。后一项发现可能表明，由于7T MRI的高敏感性，PVS计数与年龄或血管危险因素的相关性可能通过检测正常、非病理性的PVS而减弱。
Cerebral perivascular spaces (PVS) are small physiological structures around blood vessels in the brain. MRI visible PVS are associated with ageing and cerebral small vessel disease (SVD). 7 Tesla (7T) MRI improves PVS detection. We investigated the association of age, vascular risk factors, and imaging markers of SVD with PVS counts on 7 T MRI, in 50 persons aged40. The average PVS count +/- SD in the right hemisphere was 17 +/- 6 in the basal ganglia and 71 +/- 28 in the semioval centre. We observed no relation between age or vascular risk factors and PVS counts. The presence of microbleeds was related to more PVS in the basal ganglia (standardized beta 0.32; p = 0.04) and semioval centre (standardized beta 0.39; p = 0.01), and white matter hyperintensity volume to more PVS in the basal ganglia (standardized beta 0.41; p = 0.02). We conclude that PVS counts on 7T MRI are high and are related SVD markers, but not to age and vascular risk factors. This latter finding may indicate that due to the high sensitivity of 7T MRI, the correlation of PVS counts with age or vascular risk factors may be attenuated by the detection of normal, non-pathological PVS.