Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients
Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients
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DOI：
10.1016/j.jneuroim.2021.577561
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发表时间：
2021-06-03
影响因子：
3.3
通讯作者：
Pantazaki, Anastasia A.
中科院分区：
文献类型：
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作者：
Andreadou, Eleni G.;Katsipis, Georgios;Pantazaki, Anastasia A.
本研究报告了与认知健康个体相比，阿尔茨海默病（AD）和轻度认知障碍（MCI）患者血清和脑脊液（CSF）中细菌脂多糖（LPS）和环氧合酶（考克斯-1/2）水平升高，表明LPS是有希望的生物标志物，特别是在血清中。两种体液中的LPS与考克斯-1/2、A β 42和tau呈正相关，与精神状态呈负相关。此外，考克斯-2是血清中LPS存在的主要决定因素，而考克斯-1在CSF中。这些结果强调了微生物/炎症参与痴呆的重要性，并为LPS和考克斯在AD发病机制中的作用提供了新的观点。
This study reports elevated levels of bacterial lipopolysaccharides (LPSs) and cyclooxygenases (COX-1/2) in blood serum and cerebrospinal fluid (CSF) of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) patients compared to cognitively healthy individuals, indicating LPSs as promising biomarkers, especially in serum. LPSs, in both fluids, positively correlate with COX-1/2, A beta 42 and tau and negatively with mental state. Furthermore, COX-2 is the main determinant of LPSs presence in serum, whereas COX-1 in CSF. These results underline the significance of microbial/ inflammatory involvement in dementia and offer novel perspectives on the roles of LPSs and COX in pathogenesis of AD.