CRUMPLED GLOBULE MODEL OF THE 3-DIMENSIONAL STRUCTURE OF DNA
CRUMPLED GLOBULE MODEL OF THE 3-DIMENSIONAL STRUCTURE OF DNA
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DOI：
10.1209/0295-5075/23/5/012
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发表时间：
1993-08-10
期刊：
影响因子：
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通讯作者：
NEER, A
中科院分区：
文献类型：
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作者：
GROSBERG, A;RABIN, Y;NEER, A
我们认为，为了维持DNA在细胞核内的生物学功能，它的空间结构必须被解开，即所谓的类型。通过特定单元之间的吸引相互作用，固定了这种非平衡结构的特定实现，从而在DNA的空间结构和这些单元沿链轮廓的统计分布之间建立了联系。这表明原生DNA的初级序列和空间结构是通过自相似的进化过程同时形成的。我们的模型预测与最近观察到的含内含子基因和非转录调控元件的远程相关性进行了比较，并提出了进一步的实验测试。
We argue that in order to maintain the biological function of DNA confined inside the cell nucleus, its spatial structure has to be unknotted, of the so-called type. The fixation of a particular realization of this non-equilibrium structure by attractive interactions between specific units impose a connection between the spatial structure of DNA and the statistical distribution of these units along the chain contour. This suggests that both primary sequence and spatial structure of native DNA were formed simultaneously by a self-similar evolution process. The predictions of our model are compared with recent observations of long-range correlations in intron-containing genes and non-transcribed regulatory elements and further experimental tests are proposed.