POLYMODAL DOSE-RESPONSE CURVE FOR OXYTOCIN IN THE SOCIAL RECOGNITION TEST
POLYMODAL DOSE-RESPONSE CURVE FOR OXYTOCIN IN THE SOCIAL RECOGNITION TEST
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DOI：
10.1016/0143-4179(95)90029-2
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发表时间：
1995-04-01
期刊：
影响因子：
2.9
通讯作者：
ARLETTI, R
中科院分区：
文献类型：
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作者：
BENELLI, A;BERTOLINI, A;ARLETTI, R
关于催产素对记忆影响的现有数据往往不一致。在本研究中发现，成年雄性大鼠在与幼鼠接触5分钟后立即在脑室内注射催产素，剂量范围为1 fg-10 ng/大鼠，在第二次接触（120分钟后）中，成年大鼠对同一幼鼠的社会调查时间显著缩短，两次活动峰值分别为10 fg和1 ng/大鼠。大剂量的催产素无效。催产素拮抗剂d(CH2)(5)Tyr(Me)-Orn(8)- vaso催产素，在催产素前5分钟以相同的途径和剂量注射，虽然本身无效，但完全消除了低剂量催产素（1 ng/大鼠）的记忆改善作用，而转化为高剂量催产素（500 ng/大鼠）的记忆改善作用。
Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigation time of the adult rat towards the same juvenile during a second encounter (120 min later) with two peaks of activity, at 10 fg and 1 ng/rat. Larger doses of oxytocin were ineffective. The oxytocin antagonist d(CH2)(5)Tyr(Me)-Orn(8)-vasotocin, injected 5 min before oxytocin by the same route and at the same doses, while being ineffective per se, completely abolished the memory-improving effect of a low dose of oxytocin (1 ng/rat) and, on the other hand, turned into memory-improving the effect of a high dose of oxytocin (500 ng/rat).