Stressed Liver and Muscle Call on Adipocytes with FGF21.
Stressed Liver and Muscle Call on Adipocytes with FGF21.
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DOI：
10.3389/fendo.2013.00194
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发表时间：
2013-12-18
影响因子：
5.2
通讯作者：
McKeehan WL
中科院分区：
文献类型：
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作者：
Luo Y;McKeehan WL
成纤维细胞生长因子21（FGF 21）是一种新兴的局部和全身代谢稳态调节剂。用药理学水平的FGF 21治疗可减轻肥胖和相关的代谢疾病，包括糖尿病。然而，除了抗肥胖作用之外，FGF 21作为内分泌激素的正常作用和潜在机制仍不清楚。最近的一波研究表明，FGF 21是肝脏、肌肉和其他组织中的应激诱导的内分泌因子，其通过FGFR 1-betaKlotho复合物靶向脂肪组织和脂肪细胞。不同组织内的脂肪组织和脂肪细胞响应于代谢物和脂肪因子信号，其全身性地影响身体组织和邻近脂肪细胞的局部微环境内的细胞的功能。通常，这是为了防止组织特异性功能受损和对分泌FGF 21的各种组织的损伤。因此，不同的应激组织和脂肪组织及脂肪细胞通过FGF 21构成了有益的内分泌和旁分泌通讯网络。在这里，我们试图将这些发展与FGF 21对肥胖症的有益药理学作用在器官间应激通讯和机制方面统一起来。
Fibroblast growth factor 21 (FGF21) is an emerging regulator of local and systemic metabolic homeostasis. Treatment with pharmacological levels of FGF21 alleviates obesity and associated metabolic diseases including diabetes. However, beyond anti-obesogenic effects, the normal roles and underlying mechanisms of FGF21 as an endocrine hormone remain unclear. A recent wave of studies has revealed that FGF21 is a stress-induced endocrine factor in liver, muscle, and other tissues that targets adipose tissue and adipocytes through the FGFR1-betaKlotho complex. Adipose tissues and adipocytes within diverse tissues respond with metabolites and adipokine signals that affect functions of body tissues systemically and cells within the local microenvironment adjacent to adipocytes. Normally this is to prevent impaired tissue-specific function and damage to diverse tissues secreting FGF21 in response to chronic stress. Therefore, diverse stressed tissues and the adipose tissue and adipocytes constitute a beneficial endocrine and paracrine communication network through FGF21. Here we attempt to unify these developments with beneficial pharmacological effects of FGF21 on obesity in respect to inter-organ stress communication and mechanisms.