SARS-CoV-2 Antibody Response among Women Infected during Pregnancy
SARS-CoV-2 Antibody Response among Women Infected during Pregnancy
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DOI：
10.1055/s-0041-1739469
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发表时间：
2021-11-12
影响因子：
2
通讯作者：
Bianco, Angela
中科院分区：
文献类型：
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作者：
Buckley, Ayisha;Mills, Ariana;Bianco, Angela
目的由严重急性呼吸综合征-冠状病毒2型(SARS-CoV-2)病毒引起的2019年新冠状病毒病(新冠肺炎)已于2020年3月11日被世界卫生组织宣布为大流行。由于免疫变化，孕妇的免疫系统自然会降低，呼吸适应会导致肺活量下降，使她们更容易受到冠状病毒并发症的影响。在西奈山卫生系统内，每年进行超过15,000次分娩。我们从2020年3月下旬开始照顾已知感染新冠肺炎的孕妇。2020年4月初，实施了一项政策，对所有计划在西奈山卫生系统内分娩的妇女进行普遍的新冠肺炎检测。我们检测了2020年3月15日至2020年4月30日期间在西奈山医院分娩且感染SARS-CoV-2的产后妇女的抗体反应。研究设计这是一项前瞻性的观察性研究，检测在西奈山医院分娩的孕妇在聚合酶链式反应(PCR)确认感染SARS-CoV-2后的免疫反应。通过电话联系了感染SARS-CoV-2的妇女，讨论参与这项研究。同意的患者被安排进行静脉采血访问，以评估他们对新冠肺炎的抗体滴度水平。采用新冠肺炎酶联免疫吸附试验(EL ISA)、免疫球蛋白(Ig)-G抗体试验检测患者血清抗体效价。该检测方法检测在最近已知的SARS-CoV-2感染后患者中的免疫球蛋白抗体，以检测免疫球蛋白血清转换。结果共有120名患者被确认为SARS-CoV-2感染，他们在预先指定的时间范围内分娩。在这些患者中，有25名女性同意参与并纳入其中。其中64.00%是高加索人，平均年龄35岁。平均体重指数(BMI)为30 kg/m(2)，大多数患者有商业保险(88.00%)。大多数入院时无新冠肺炎症状的妇女(80.00%)，分娩和诊断新冠肺炎的平均孕周为39周。确诊时胎龄越晚，抗体滴度反应越低。在检查从诊断到抗体滴度分析的时间间隔时，滴度最高的患者(2,880)从确诊为新冠肺炎到滴度水平测定的时间间隔往往较短。与无症状的女性相比，入院时有症状的患者的抗体效价水平相似。结论孕期感染新冠肺炎的孕妇在孕期确诊时，其抗体反应可能更强。
Objectives Novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus has been declared a pandemic by the World Health Organization as of March 11, 2020. Pregnant women naturally have a reduced immune system due to immunological changes and decreased lung capacity due to respiratory adaptations, making them more susceptible to coronavirus complications. Within the Mount Sinai Health system, more than 15,000 deliveries are performed annually. We began to care for pregnant women with known COVID-19 infections in late March of 2020. In early April 2020, a policy was implemented to perform universal COVID-19 testing for all women planning to deliver within the Mount Sinai Health system. We examined the antibody response of postpartum women who delivered at Mount Sinai Hospital with a SARS-CoV-2 infection between the study intervals during March 15, 2020, through April 30, 2020. Study Design This was a prospective observational study examining the immune response of pregnant women who delivered at Mount Sinai Hospital with a polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection. Women with a SARS-CoV-2 infection were contacted via phone to discuss participation in the study. Patients who consented were scheduled for a phlebotomy visit to assess their antibody titer levels to COVID-19. The COVID-19 enzyme-linked immunosorbent assay (ELISA) immunoglobulin (Ig)-G antibody test was used to evaluate the patients' antibody titers. The assay detects IgG antibodies for the detection of IgG seroconversion in patients following a known recent SARS-CoV-2 infection. Results A total of 120 patients were identified with a documented SARS-CoV-2 infection who delivered within the prespecified time frame. Of those patients, 25 women agreed to participate and were included. Of them, 64.00% were Caucasian with a mean age of 35 years. The mean body mass index (BMI) was 30 kg/m (2) and the majority of patients had commercial insurance (88.00%). The majority of women were asymptomatic for COVID-19 at the time of admission (80.00%) and the average gestational age of delivery and diagnosis of COVID-19 was 39 weeks' gestation. The later the gestational age at the time of diagnosis, the lower the antibody titer response. When examining the interval from diagnosis to antibody titer analysis, patients with the highest titers (2,880) tended to have a shorter interval between their COVID-19 diagnosis and the time at which the titer level was drawn. Patients with symptoms on admission had similar antibody titer levels when compared with women who were asymptomatic. Conclusion The antibody response among women infected with COVID-19 during pregnancy appears to be greater when the patients are diagnosed at an earlier gestational age.