Endometriosis fertility index score maybe more accurate for predicting the outcomes of in vitro fertilisation than r-AFS classification in women with endometriosis.
Endometriosis fertility index score maybe more accurate for predicting the outcomes of in vitro fertilisation than r-AFS classification in women with endometriosis.
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DOI：
10.1186/1477-7827-11-112
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发表时间：
2013-12-11
期刊：
影响因子：
--
通讯作者：
Yang D
中科院分区：
文献类型：
--
作者：
Wang W;Li R;Fang T;Huang L;Ouyang N;Wang L;Zhang Q;Yang D
子宫内膜异位症是一种常见病。最广泛使用的子宫内膜异位症分期系统是修订的美国生育协会分类（r-AFS分类），其对术后妊娠的预测能力有限。子宫内膜异位症生育指数（EIT）用于预测子宫内膜异位症手术后的生育能力。这项诊断准确性研究旨在比较子宫内膜异位症患者IVF结局的r-AFS分类与r-AFS分类的预测价值。对199例子宫内膜异位症术后接受IVF治疗的妇女进行了分析。在同一人群中比较了IVF评分和r-AFS分类预测这些IVF结局的能力。采用ROC曲线分析R-AFS和R-AFS指标对临床妊娠的预测价值，并以敏感性、特异性和Youden指数评价其准确性。评分的曲线下面积（AUC）（AUC = 0.641，标准误（SE）= 0.039，P = 0.001，95%CI = 0.564-0.717，cut-off score = 6）显著大于r-AFS分类（AUC = 0.445，SE = 0.041，P = 0.184，95%CI = 0.364-0.526）。窦卵泡数、hCG日雌二醇水平、获卵数、受精卵数、卵裂胚数≥ 6分组均高于≤ 5分组，≥ 6分组促性腺激素用量少于≤ 5分组。≥ 6分组的种植率、临床妊娠率和累积妊娠率均高于≤ 5分组。这表明子宫内膜异位症患者IVF结局的预测能力高于r-AFS分类。临床妊娠率在≥ 6分者高于≤ 5分者。
Endometriosis is a common disease. The most widely used staging system of endometriosis is the revised American Fertility Society classification (r-AFS classification) which has limited predictive ability for pregnancy after surgery. The endometriosis fertility index (EFI) is used to predict fecundity after endometriosis surgery. This diagnostic accuracy study was designed to compare the predictive value of the EFI with that of the r-AFS classification for IVF outcomes in patients with endometriosis. 199 women with endometriosis receiving IVF treatment after surgery were analysis. The EFI score and r-AFS classification in their ability to predict these IVF outcomes were compared in the same population. ROC curves were used to analyse the predictive values of the EFI and r-AFS indices for clinical pregnancy, and their accuracies were evaluated by sensitivity, specificity, and the Youden’s index. The Area Under the Curve (AUC) of the EFI score (AUC = 0.641, Standard Error(SE) = 0.039, P = 0.001, 95% CI = 0.564-0.717, cut-off score = 6) was significantly larger than that of the r-AFS classification (AUC = 0.445, SE = 0.041, P = 0.184, and 95% CI = 0.364-0.526). The antral follicle count, oestradiol level on day of hCG, number of oocytes retrieved, number of oocytes fertilised, and number of cleaved embryos in the greater than or equal to 6 EFI score group was greater than that of the lower than or equal to 5 EFI score group, and the dose of gonadotropin of the greater than or equal to 6 EFI score group were less than that in the lower than or equal to 5 EFI score group. Implantation rate, clinical pregnancy rate, and cumulative pregnancy rate in the greater than or equal to 6 EFI score group were higher than in the lower than or equal to 5 EFI score group. It suggests that the EFI has more predictive power for IVF outcomes in endometriosis patients than the r-AFS classification. The clinical pregnancy rate was higher in patients with EFI greater than or equal to 6 score than with EFI lower than or equal to 5 score.
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影响因子：
2.1
作者：
Tavmergen, Erol;Ulukus, Murat;Goker, Ege Nazan Tavmergen
通讯作者：
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影响因子：
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DOI：
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发表时间：
1951-01-01
影响因子：
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作者：
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通讯作者：
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影响因子：
6.7
作者：
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