Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes [published erratum appears in J Exp Med 1995 Mar 1;181(3):1261]
Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes [published erratum appears in J Exp Med 1995 Mar 1;181(3):1261]
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编码由 HLA-A31 限制性肿瘤浸润淋巴细胞识别的黑色素瘤肿瘤抗原的基因的鉴定 [已发表的勘误表出现在 J Exp Med 1995 Mar 1;181(3):1261]
DOI：
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发表时间：
1995
影响因子：
15.3
通讯作者：
Steven A. Rosenberg
中科院分区：
文献类型：
--
作者：
Rongfu Wang;P. Robbins;Yutaka Kawakami;X. Kang;Steven A. Rosenberg
抗肿瘤细胞毒性T淋巴细胞的可用性，它可以产生从外周血淋巴细胞刺激后在体外或肿瘤浸润淋巴细胞（TIL）已经有可能确定一些黑色素瘤抗原提出的主要组织相容性复合物I类分子。目前和以前的研究表明，TIL 586识别在大多数黑色素瘤和正常黑色素细胞上表达的抗原，其背景是HLA-A31分子。我们在这里报告的克隆的cDNA，指导共同的黑色素瘤抗原的表达，该识别的TIL。DNA序列分析显示，该cDNA与编码酪氨酸酶相关蛋白1或糖蛋白gp 75的基因几乎相同，该基因最初通过黑色素瘤患者的血清抗体鉴定。发现该基因仅在黑色素瘤、正常黑素细胞系和视网膜中表达，但在其他测试的正常组织中不表达。因此，由HLA-A31呈递的gp 75抗原可以构成用于黑素瘤患者的特异性治疗的有用的免疫靶标，因为抗体和T细胞介导的免疫应答都可以针对该抗原产生。
The availability of antitumor cytotoxic T lymphocytes which can be generated from either peripheral blood lymphocytes after stimulation in vitro or tumor infiltrating lymphocytes (TIL) has made it possible to identify a number of melanoma antigens presented by major histocompatibility complex class I molecules. The present and previous studies indicated that TIL586 recognized an antigen expressed on most melanoma and normal melanocytes in the context of the HLA-A31 molecule. We report here the cloning of a cDNA that directs the expression of the shared melanoma antigen recognized by this TIL. The DNA sequence analysis revealed that the cDNA was almost identical to the gene encoding tyrosinase-related protein 1 or glycoprotein gp75 which was originally identified by serum antibodies in a patient with melanoma. The gene was found to be expressed only in melanoma, normal melanocyte cell lines, and retina, but not in other normal tissues tested. The gp75 antigen presented by HLA-A31 may therefore constitute a useful immune target for specific treatment of patients with melanoma, since both antibody- and T cell-mediated immune responses can be generated against this antigen.
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DOI：
10.1038/jid.1993.73
发表时间：
1993-02
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Ruth Halaban;Gisela Moellmann
通讯作者：
Ruth Halaban;Gisela Moellmann
使用 HLA-A2 匹配的同种异体黑色素瘤生成人类自体黑色素瘤特异性细胞毒性 T 细胞。
影响因子：
11.2
作者：
Crowley,NJ;SlingluffJr,CL;Darrow,TL;Seigler,HF
通讯作者：
Seigler,HF
DOI：
10.1073/pnas.87.7.2833
发表时间：
1990-04-01
影响因子：
11.1
作者：
ENNIS, PD;ZEMMOUR, J;PARHAM, P
通讯作者：
PARHAM, P
来自人类脉络膜黑色素瘤的肿瘤浸润淋巴细胞的研究。
影响因子：
4.4
作者：
Ksander,BR;Rubsamen,PE;Olsen,KR;Cousins,SW;Streilein,JW
通讯作者：
Streilein,JW