Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial.
Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial.
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DOI：
10.1186/1742-4933-7-11
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发表时间：
2010-08-26
期刊：
影响因子：
--
通讯作者：
Kohda N
中科院分区：
文献类型：
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作者：
Kotani Y;Shinkai S;Okamatsu H;Toba M;Ogawa K;Yoshida H;Fukaya T;Fujiwara Y;Chaves PH;Kakumoto K;Kohda N
唾液中的免疫球蛋白A（伊加）分泌随着年龄的增长而减少，这可能是老年人对呼吸道感染的易感性增加的原因。口服乳酸菌对老年人唾液分泌伊加（SIgA）的影响尚未见报道。本研究的目的是证明老年人口服戊糖乳杆菌菌株b240（b240）可加速唾液SIgA分泌。总共80名健康老年人被随机分配到干预组（即，B240）或对照（即，安慰剂组。b240组的老年人被给予含有热灭活的b240（4 × 109个细胞）的无菌水饮料（125 mL），而安慰剂组的老年人仅被给予无菌水饮料（125 mL）;两组每天接受一次各自的饮料，持续12周。在研究开始前和之后每2周一次收集唾液。测定唾液流率和唾液SIgA浓度，计算唾液SIgA分泌率。b240组的平均唾液SIgA分泌率稳定增加，直到第4周（相对于第0周升高20%），然后保持稳定，直到第12周。干预期间，b240组SIgA分泌率的变化显著大于安慰剂组。治疗组在不良事件方面没有表现出显著差异。口服L.戊糖菌株b240 12周显著加速唾液SIgA分泌，从而表明其在改善老年人的粘膜免疫和抗感染性中的潜在效用。
Immunoglobulin A (IgA) secretion in saliva decreases with age and may be the cause of increased vulnerability of the elderly to respiratory infections. The effect of oral intake of lactic acid bacteria on salivary secretory IgA (SIgA) in the elderly has not been reported. The objective of this study was to demonstrate the acceleration of salivary SIgA secretion by oral intake of Lactobacillus pentosus strain b240 (b240) in the elderly. A total of 80 healthy elderly individuals were randomly allocated to either an intervention (i.e., b240) or a control (i.e., placebo) group. The elderly individuals in the b240 group were given a sterile water beverage (125 mL) containing heat-killed b240 (4 × 109 cells), while those in the placebo group were given only a sterile water beverage (125 mL); both groups received their respective beverages once daily for 12 weeks. Saliva was collected before initiation of the study and every 2 weeks thereafter. Saliva flow rate and SIgA concentration were determined, and the SIgA secretion rate was calculated. The mean salivary SIgA secretion rate in the b240 group steadily increased until week 4 (exhibiting a 20% elevation relative to that at week 0), and then remained stable until week 12. Changes in SIgA secretion rate over the intervention period were significantly greater in the b240 group than in the placebo group. The treatment groups exhibited no significant differences in adverse events. Oral intake of L. pentosus strain b240 for 12 weeks significantly accelerated salivary SIgA secretion, thereby indicating its potential utility in the improvement of mucosal immunity and resistance against infection in the elderly.