COLCHICINE - A COMMON MECHANISM FOR ITS ANTI-INFLAMMATORY AND ANTI-MITOTIC EFFECTS
COLCHICINE - A COMMON MECHANISM FOR ITS ANTI-INFLAMMATORY AND ANTI-MITOTIC EFFECTS
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DOI：
10.1002/art.1780110210
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发表时间：
1968-01-01
影响因子：
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通讯作者：
MALAWISTA, SE
中科院分区：
文献类型：
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作者：
MALAWISTA, SE
小剂量的秋水仙碱是一种弱的、普通的抗炎药。目前尚不清楚为什么这种药物只对(人类)急性痛风性关节炎和其他一些炎症性疾病(如结节性关节炎，也许还有结节性红斑伴关节炎)有效。然而，这一临床观察最终可能有助于确定这类疾病的炎症机制的差异。根据秋水仙碱在不同细胞类型中的作用，得出了秋水仙碱作用的一般公式，其中分裂过程中有丝分裂纺锤体的破坏是一个特例。秋水仙素似乎干扰了细胞中与结构和运动有关的不稳定的纤维系统(原生质凝胶)的组织。长春花碱和灰黄霉素[长划线]都是中期阻滞剂[长划线]，它们与秋水仙碱具有某些其他作用，这支持了关于抗有丝分裂和抗炎特性的共同基础的建议。
Colchicine in low dosage is a weak, general anti-inflammatory agent. It is not clear at present why the drug is useful only in [human] acute gouty arthritis and a few other inflammatory disorders (such as sarcoid arthritis, and perhaps erythema nodosum with arthritis). This clinical observation may eventually be useful, however, in defining differences in the mechanism of inflammation in this group of diseases. From the effects of colchicine in various cell types, a general formulation was drawn for the action of colchicine, in which disruption of the mitotic spindle in dividing cells is a special case. Colchicine seems to interfere in cells with the organization of labile fibrillar systems (protoplasmic gels) concerned with structure and movement. Vinblastine and griseofulvin[long dash]both of which are metaphase-arresting agents[long dash]share certain other effects with colchicine that support the suggestion of a common basis for anti-mitotic and anti-inflammatory properties.