Relationships between skin's electrical impedance and permeability in the presence of chemical enhancers
Relationships between skin's electrical impedance and permeability in the presence of chemical enhancers
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DOI：
10.1016/j.jconrel.2005.10.012
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发表时间：
2006-01-10
影响因子：
10.8
通讯作者：
Mitragotri, S
中科院分区：
文献类型：
--
作者：
Karande, P;Jain, A;Mitragotri, S
角质层是皮肤的最外层，为溶质和离子的移动提供了强大的屏障。我们报告了在33种不同的化学渗透促进剂配方中，皮肤的电阻抗与其对亲水性(甘露醇和菊粉)以及疏水性(皮质酮和雌二醇)溶液的渗透性之间的关系。对于亲水性的溶质，阻抗与渗透率的相关性很好(r(2)=0.8)，对于疏水性的溶质，阻抗与渗透率的相关性中等但显著(r(2)=0.5)。定量评估了使用皮肤的电阻抗来选择有效配方的可能性。渗透促进剂的百分位数排名基于它们对皮肤电阻抗的影响，与基于它们对溶质渗透性的影响的排名很好地吻合(甘露醇和雌二醇都是r(2)>；0.9)。这些研究证明了利用皮肤的电阻抗来筛选有效的化学促进剂的可行性。(C)2005 Elsevier B.V.保留所有权利。
Stratum corneum, the outermost layer of the skin, offers a strong barrier to the movement of solutes as well as ions. We report on the existence of a relationship between skin's electrical impedance and its permeability to hydrophilic (mannitol and inulin) as well as hydrophobic (corticosterone and estradiol) solutes in the presence of 33 distinct chemical penetration enhancer formulations. The correlation between impedance and permeability was excellent (r(2) = 0.8) for hydrophilic solutes and moderate, yet significant (r(2) = 0.5), for hydrophobic solutes. The possibility of using skin's electrical impedance to choose potent formulations was quantitatively assessed. Percentile ranking of penetration enhancers based on their effect on skin's electrical impedance matched well with the ranking based on their effect on solute permeability (r(2) > 0.9 for both mannitol and estradiol). These studies demonstrate the feasibility of using skin's electrical impedance to screen potent chemical enhancers. (c) 2005 Elsevier B.V. All rights reserved.