Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk
Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk
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DOI：
10.1017/s0033291711000973
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发表时间：
2012-01-01
影响因子：
6.9
通讯作者：
Henquet, C.
中科院分区：
文献类型：
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作者：
Konings, M.;Stefanis, N.;Henquet, C.
背景大麻使用和童年创伤或虐待协同增加以后发展精神病症状的风险的概念可能具有生物学上的合理性。为了复制和进一步调查这个问题，前瞻性数据从两个独立的人群为基础的研究，希腊国家围产期研究（n=1636）和荷兰精神健康调查和发病率研究（NEMESIS）（n=4842），进行了分析。使用了关于大麻使用和儿童虐待的两组不同数据。在一项以希腊人口为基础的大型队列研究中，对19岁时大麻使用和7岁时儿童虐待的数据进行了评估。此外，精神病症状使用社区精神体验评估（CAPE）进行评估。在NEMESIS中，使用复合国际诊断访谈（CIDI）评估沿着儿童期虐待和终生大麻使用的三个不同时间点的精神病症状。在两个样本中，儿童期虐待和后来使用大麻之间的显著调整后的相互作用是明显的，表明大麻的精神病诱导作用在早期暴露于性虐待或身体虐待的个体中更强[希腊国家围产期研究：相互作用检验F（2，1627）= 4.18，p=0.02; NEMESIS：交互作用检验χ（2）（3）=8.08，p=0.04]。儿童期虐待和大麻使用之间的交叉敏感性可能存在于形成阳性精神病症状表达风险的途径中。
Background. There may be biological plausibility to the notion that cannabis use and childhood trauma or maltreatment synergistically increase the risk for later development of psychotic symptoms. To replicate and further investigate this issue, prospective data from two independent population-based studies, the Greek National Perinatal Study (n=1636) and The Netherlands Mental Health Survey and Incidence Study (NEMESIS) (n=4842), were analyzed.Method. Two different data sets on cannabis use and childhood maltreatment were used. In a large Greek population-based cohort study, data on cannabis use at age 19 years and childhood maltreatment at 7 years were assessed. In addition, psychotic symptoms were assessed using the Community Assessment of Psychic Experiences (CAPE). In NEMESIS, the Composite International Diagnostic Interview (CIDI) was used to assess psychotic symptoms at three different time points along with childhood maltreatment and lifetime cannabis use.Results. A significant adjusted interaction between childhood maltreatment and later cannabis use was evident in both samples, indicating that the psychosis-inducing effects of cannabis were stronger in individuals exposed to earlier sexual or physical mistreatment [Greek National Perinatal Study: test for interaction F(2, 1627)= 4.18, p=0.02; NEMESIS: test for interaction chi(2)(3)=8.08, p=0.04].Conclusions. Cross-sensitivity between childhood maltreatment and cannabis use may exist in pathways that shape the risk for expression of positive psychotic symptoms.