Update on the PennPET Explorer: A Whole-body Imager with Scalable Axial Field-of-View.
Update on the PennPET Explorer: A Whole-body Imager with Scalable Axial Field-of-View.
复制标题
PennPET Explorer 的更新：具有可扩展轴向视野的全身成像仪。
DOI：
10.1016/j.cpet.2020.09.002
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发表时间：
2021
期刊：
影响因子：
2.6
通讯作者：
Karp,JoelS
中科院分区：
文献类型：
--
作者：
Pantel,AustinR;Viswanath,Varsha;Karp,JoelS
正电子发射断层扫描 (PET) 仪器的进步彻底改变了临床 PET 成像。现代 PET 扫描仪可以在多个床位上对整个身体进行成像，通常需要 10 分钟到 15 分钟，从而能够有效地对疾病进行分子表征。然而，最终，商用扫描仪有限的轴向视场 (AFOV) 限制了整体灵敏度和同时对不同器官进行成像的能力。 1受增加 AFOV 的理论优势的推动，美国国立卫生研究院资助的 EXPLORER 联盟开发了 2 款全身 (TB) 扫描仪2：宾夕法尼亚大学的 PennPET Explorer 和加州大学戴维斯分校的 uEXPLORER。在此，讨论 PennPET Explorer； uEXPLORER 将在本期 PET Clinics 中单独详细讨论。这两款扫描仪均基于商用 PET 扫描仪的技术，并与行业合作伙伴合作：联影医疗（中国上海）的 uEXPLORER 和飞利浦医疗（俄亥俄州克利夫兰）的 PennPET Explorer。虽然 uEXPLORER 的 2 米AFOV 使其成为真正的全身成像仪，并且比 PennPET Explorer 的 AFOV 更大，但这两种仪器都可以在单床位上以高灵敏度对身体的所有主要器官进行成像。 3-6
Advances in positron emission tomography (PET) instrumentation have revolutionized clinical PET imaging. Modern PET scanners can image the entire body over multiple bed positions, typically in 10 minutes to 15 minutes, enabling efficient molecular characterization of disease. Ultimately, however, the limited axial field of view (AFOV) of commercial scanners limits overall sensitivity and the ability to image disparate organ simultaneously. 1Motivated by the theoretic benefits of an increased AFOV, the National institutes of Healthfunded EXPLORER Consortium led to the development of 2 total-body (TB) scanners2: the PennPET Explorer, based at the University of Pennsylvania, and the uEXPLORER, based at University of California, Davis. Herein, the PennPET Explorer is discussed; the uEXPLORER is discussed in detail separately in this issue of PET Clinics. Both scanners are based on technology from commercial PET scanners with collaboration from industry partners: United Imaging Healthcare (Shanghai, China) for the uEXPLORER and Philips Healthcare (Cleveland, Ohio) for the PennPET Explorer. Although the 2-m AFOV of the uEXPLORER makes it truly a total-body imager and is greater than that of the AFOV of the PennPET Explorer, both instruments image all major organs in the body with high sensitivity in a single bed position. 3–6