Localization of the L1Md family of repeated sequences in the mouse albumin-alpha-fetoprotein gene complex.
Localization of the L1Md family of repeated sequences in the mouse albumin-alpha-fetoprotein gene complex.
复制标题
小鼠白蛋白-甲胎蛋白基因复合物中重复序列 L1Md 家族的定位。
DOI：
10.1093/nar/12.16.6575
复制
发表时间：
1984
影响因子：
14.9
通讯作者：
Papaconstantinou,J
中科院分区：
文献类型：
--
作者：
Cooper,R;Herzog,CE;Li,ML;Zapisek,WF;Hoyt,PR;Ratrie3rd,H;Papaconstantinou,J
对小鼠β-珠蛋白基因复合体的研究表明，存在散布在基因间区域的重复DNA序列（1，2）。这些序列是中间重复序列家族的成员，并已定位于60 kbp β-珠蛋白复合物中的特定基因间位点。在这项研究中，我们提出的证据表明，这个中间重复的DNA序列家族，L1 Md家族的成员，散布在整个小鼠白蛋白和甲胎蛋白基因复合物。与β-珠蛋白复合物的那些序列不同，这些序列都存在于基因间区域中，这些序列位于白蛋白基因的内含子12和AFP基因的内含子3内，并且在连接白蛋白基因和AFP基因的13.5 kbp基因间区域中有两次。
Studies on the β-globin gene complex in the mouse have demonstrated the existence of repeated DNA sequences interspersed throughout the intergenic regions (1,2). These sequences are members of families of middle repetitive sequences and have been mapped to specific intergenic sites in the 60 kbp β-globin complex. In this study we present evidence that members of this middle repetitive family of DNA sequences, the L1Md family, are interspersed throughout the mouse albumin and α-fetoprotein gene complex. Unlike those of the β-globin complex, all of which are found in the intergenic regions, these sequences are localized within intron 12 of the albumin gene and intron 3 of the AFP gene as well as twice in the 13.5 kbp intergenic region that links the albumin gene to the AFP gene.