Plain radiography in the evaluation of knee osteoarthritis.
Plain radiography in the evaluation of knee osteoarthritis.
复制标题
平片在评估膝骨关节炎中的应用。
DOI：
10.1097/00002281-199705000-00015
复制
发表时间：
1997
影响因子：
5.1
通讯作者：
Mazzuca,S
中科院分区：
文献类型：
--
作者：
Mazzuca,S
在人类中对疾病修饰骨关节炎药物的对照研究结果的前景已经引起了人们对放射学方法的兴趣，以检测早期软骨损伤并评估膝关节骨关节炎中的进行性软骨变化。我们在此总结了膝关节X线平片中的技术因素-/e、膝关节屈曲程度、X线束的错位、关节X线图像的放大倍数-以及测量程序在多大程度上会影响胫股关节间隙宽度定量测量的可重复性，胫股关节间隙宽度是关节软骨厚度的替代物。如果不能标准化传统膝关节X线摄影的关键要素和胫股关节间隙宽度的计算机测量，将在X线摄影结果数据中引入显著的（可能是无法克服的）误差变化。X线透视辅助的膝关节屈曲和足部旋转以及关节间隙宽度的计算机化放大校正测量可达到的精确度水平大大提高了改善疾病的骨关节炎药物试验的可行性，因为它们与检测改善疾病的骨关节炎药物的效果所需的样本量和治疗持续时间有关。
The prospects for results of controlled studies of disease-modifying osteoarthritis drugs in humans have fostered interest in radiographic methods to detect early cartilage damage and to assess progressive cartilage changes in osteoarthritis of the knee. We summarize here the extent to which technical factors in plain knee radiography-/e, the degree of knee flexion, misalignment of the x-ray beam, magnification of the radiographic image of the joint-and mensural procedures can impact the reproducibility of quantitative measurements of tibiofemoral joint space width, the surrogate for thickness of articular cartilage. Failure to standardize crucial elements of conventional knee radiography and to computerize measurement of tibiofemoral joint space width will introduce significant (and probably insurmountable) error variation into radiographic outcome data. The level of precision achievable with fluoroscopically-assisted flexion of the knee and rotation of the foot with computerized, magnification-corrected measurement of joint space width greatly improves the feasibility of disease-modifying osteoarthritis drug trials as they relate to sample size and duration of treatment necessary to detect an effect from disease-modifying osteoarthritis drugs.