LESIONS OF THE SUPRACHIASMATIC NUCLEI AND THE SEROTONIN-DEPENDENT PHASIC RELEASE OF LUTEINIZING-HORMONE IN THE RAT - EFFECTS ON DRINKING RHYTHMICITY AND ON THE CONSEQUENCES OF PREOPTIC AREA STIMULATION
LESIONS OF THE SUPRACHIASMATIC NUCLEI AND THE SEROTONIN-DEPENDENT PHASIC RELEASE OF LUTEINIZING-HORMONE IN THE RAT - EFFECTS ON DRINKING RHYTHMICITY AND ON THE CONSEQUENCES OF PREOPTIC AREA STIMULATION
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DOI：
10.1677/joe.0.0840231
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发表时间：
1980-01-01
影响因子：
4
通讯作者：
MACKINNON, PCB
中科院分区：
文献类型：
--
作者：
COEN, CW;MACKINNON, PCB
Ovariectomized rats in which < 7% of the suprachiasmatic nuclei was spared by bilateral radiofrequency lesions were distinguishable from those with > 40% of the nuclei by their consistent failure to show the estrogen-induced daily LH [luteinizing hormone, lutropin], surge, either with or without pharmacological manipulations of serotonin (5-HT), and also by their loss of the normal rhythmicity of drinking. Minor damage to structures adjacent to the suprachiasmatic nuclei was similar in both groups. The identical facility with which electrical stimulation of the preoptic area induced LH release in the 2 groups of animals suggested that they were not characterized by different degrees of damage to the preopticotuberal pathway. The suprachiasmatic nuclei apparently represent the densest concentration of 5-HT terminals in the forebrain and also the site of a mechanism involved in the generation of circadian rhythms.
