Vascular endothelial growth factor plays an important autocrine/paracrine role in the progression of osteoarthritis
Vascular endothelial growth factor plays an important autocrine/paracrine role in the progression of osteoarthritis
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DOI：
10.1007/s00418-005-0773-6
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发表时间：
2005-03-01
影响因子：
2.3
通讯作者：
Tanne, K
中科院分区：
文献类型：
--
作者：
Tanaka, E;Aoyama, J;Tanne, K
血管内皮生长因子（VEGF）在软骨生长的血管生成中发挥重要作用。尽管正常成人软骨中的 VEGF 表达消失，但已知 VEGF 在骨关节炎 (OA) 软骨的软骨细胞中表达。由于有关颞下颌关节 (TMJ) OA 样病变软骨中 VEGF 表达的信息很少，因此检查了 OA 大鼠 TMJ 髁突软骨中的 VEGF 表达。为了诱发 OA，通过强迫下颌张开 10 或 20 天来施加机械应力。 20天后，在髁突中观察到明显的骨关节炎样病变。 VEGF在髁突中部和后部成熟和肥大细胞层的软骨细胞中表达。 VEGF 免疫阳性软骨细胞的百分比随着施加机械应力的时间显着增加。此外，髁软骨的抗酒石酸酸性磷酸酶（TRAP）染色显示，肥大层下方的矿化层中破骨细胞显着增加，肥大层可检测到高 VEGF 表达。结果表明VEGF在OA的进展中发挥重要作用。
Vascular endothelial growth factor (VEGF) plays an essential role in the angiogenesis of growing cartilage. Although VEGF expression in cartilage vanishes in normal adults, VEGF is known to be expressed in chondrocytes of osteoarthritic (OA) cartilage. As little information is available on the VEGF expression in the cartilage of OA-like lesions of the temporomandibular joint (TMJ), VEGF expression in the condylar cartilage of TMJs of rats affected with OA was examined. To evoke OA, mechanical stress was applied by forced jaw opening for 10 or 20 days. After 20 days, marked OA-like lesions were observed in the condyle. VEGF was expressed in the chondrocytes of the mature and hypertrophic cell layers of the intermediate and posterior region of the condyle. The percentage of VEGF immunopositive chondrocytes significantly increased with the period of applied mechanical stress. Furthermore, tartrate-resistant acid phosphatase (TRAP) staining of the condylar cartilage showed significant increment of osteoclasts in the mineralized layer subjacent to the hypertrophic layer where high VEGF expression could be detected. The results suggest that VEGF plays an important role in the progression of OA.