IFN-gamma, IL-5, IL-6 and IgE in patients infected with Giardia intestinalis
IFN-gamma, IL-5, IL-6 and IgE in patients infected with Giardia intestinalis
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DOI：
10.2478/v10042-009-0013-3
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发表时间：
2009-01-01
影响因子：
1.5
通讯作者：
Kemona, Halina
中科院分区：
文献类型：
--
作者：
Matowicka-Karna, Joanna;Dymicka-Piekarska, Violetta;Kemona, Halina
免疫系统，其细胞和体液反应，是由宿主生物体对抗寄生虫感染。研究组包括90例G.好吧根据实验室检查（粪便检查、胆道镜检查、GSA-65）确定诊断。在抗寄生虫治疗前（G1）、治疗后2周（G2）和2个月（G3）采集用于分析的血液。对照组为40例健康志愿者，男18例，女22例，年龄20-45岁。使用一套VIDAS（bioMerieux）测定IgE的浓度，并使用一套Quantikine human（R&D Systems）测定IL-5、IL-6、IFN-γ的浓度。结果表明，与健康对照相比，贾第虫病患者血清中IgE和IL-5的浓度高两倍，IL-6的浓度高2.5倍，IFN-γ的浓度几乎高4倍。
The immune system, its cellular and humoral response, is engaged by the host organism to fight against parasitic infections. The study group consisted of 90 patients (58 women and 32 men), aged 18-72 years, infected with G. intestinalis. The diagnosis was established based on laboratory investigations (stool examination, choloscopy, GSA-65). Blood for analysis was collected before (G1), and 2 weeks (G2) and 2 months (G3) after antiparasitic treatment. Control group consisted of 40 healthy subjects (22 women and 18 men), aged 20-45 years. The concentrations of IgE were assayed using a set of VIDAS (bioMerieux) and the concentrations of IL-5, IL-6, IFN-gamma were determined using a set of Quantikine human (R&D Systems). It was revealed that in giardiosis the concentrations of IgE and IL-5 in blood serum were twice as high, the concentration of IL-6 was two and a half times higher and the concentration of IFN-gamma was almost four times higher as compared to healthy controls.