The molecular pathology of Friend erythroleukemia virus strains. An overview.
The molecular pathology of Friend erythroleukemia virus strains. An overview.
复制标题
弗兰德红白血病病毒株的分子病理学。
DOI：
10.1016/0304-419x(85)90002-2
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Pogo,BG
中科院分区：
文献类型：
--
作者：
Friend,C;Pogo,BG
鼠类 Friend 白血病病毒 (FLV) 被广泛用于研究肿瘤病毒学的许多方面。白血病组织对体外生长的适应以及细胞具有沿着红细胞途径分化的能力的证明，提供了已成为在细胞、遗传、生化和分子水平上研究分化和红细胞生成的标准模型的系统。然而，尽管人们对逆转录病毒的遗传结构、组织和复制的详细了解正在以惊人的速度积累，但病毒引起的红细胞白血病的分子途径仍未完全了解。问题源于这样一个事实：自病毒分离以来，在病毒漫长而多样的传代历史过程中，产生了许多不同的毒株。这些菌株的生物学和生化特性各不相同。哪种特性对于赋予 FLV 产生由原始分离株诱导的恶性综合征的能力是必要和充分的问题尚未得到令人满意的回答，特别是因为分子克隆病毒在宿主范围、潜伏期、年龄依赖性和病理学方面与野生型病毒不同。在这篇综述中，我们试图将病毒学的最新进展与细胞生物学和病理学联系起来，以期阐明这些差异的分子基础。对于此处讨论的特定方面的全面评论，读者将被引导至参考文献。 6a、9、10、16、59和59a。
The murine Friend leukemia virus (FLV) is being widely used to study many aspects of tumor virology. The adaptation of the leukemic tissues to in vitro growth and the demonstration that the cells had the capacity to differentiate along the erythroid pathway, provided systems which have become the standard models for studies on differentiation and erythropoiesis at the cellular, genetic, biochemical and molecular levels. The molecular pathway of the virus-induced eryth~ oleukemia, however, remains incompletely understood, notwithstanding the detailed knowledge of the genetic structures, organization and replication of retroviruses that is accumulating at a phenomenal rate. The problem stems from the fact that a number of different strains have been generated in the course of the long and varied passage history of the virus since its isolation. These strains differ from each other on the basis of their biological and biochemical properties. The question of which property (ies) is (are) necessary and sufficient to endow FLV with the capacity to produce the malignant syndrome induced by the original isolate has not been satisfactorily answered, particularly since molecularly cloned viruses differ from the wild-type virus in host range, latent period, age dependence and pathology. In this review we have tried to correlate the recent advances in virology with the cell biology and pathology in an effort to clarify the molecular basis of these differences. For comprehensive reviews on specific aspects discussed here, the reader will be directed to Refs. 6a, 9, 10, 16, 59 and 59a.