Axial T2* mapping in intervertebral discs: a new technique for assessment of intervertebral disc degeneration
Axial T2* mapping in intervertebral discs: a new technique for assessment of intervertebral disc degeneration
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DOI：
10.1007/s00330-012-2448-8
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发表时间：
2012-09-01
影响因子：
5.9
通讯作者：
Benneker, Lorin M.
中科院分区：
文献类型：
--
作者：
Hoppe, Sven;Quirbach, Sebastian;Benneker, Lorin M.
为了证明在临床环境中使用1.5特斯拉磁共振成像(MRI)对腰椎间盘(IVD)进行生化轴向T2*标测对于早期退行性腰椎间盘疾病的检测和分级的潜在益处。93名腰椎问题患者使用包括轴向T2*标测方案的标准MRI方案进行检查。所有椎间盘均按形态分类，分为“健康”或“异常”两类。分析不同感兴趣区(ROI)的T2*值在不同组间的差异。健康腰椎间盘显示出明显的T2*值分布：纤维环的T2*值显著低于髓核(P=0.01)。在异常的IVD中，T2*值显著降低，尤其是向椎间盘中心的方向，代表了预期的髓核水分含量下降(P=0.01)。在突出的椎间盘中，髓核内的感兴趣区和覆盖纤维环的感兴趣区显示T2*值降低。轴位T2*标测是发现退行性腰椎间盘疾病早期的有效方法。轴位T2*图作为一种诊断工具有一个潜在的好处，可以对椎间盘退变进行定量评估。Euro Center轴位T2*图在检测早期退行性腰椎间盘疾病方面有效。Euro Center健康和异常的腰椎间盘显示出明显的横断面T2*值轮廓。在临床环境中，Euro Center T2*可以在1.5T下进行。
To demonstrate the potential benefits of biochemical axial T2* mapping of intervertebral discs (IVDs) regarding the detection and grading of early stages of degenerative disc disease using 1.5-Tesla magnetic resonance imaging (MRI) in a clinical setting.Ninety-three patients suffering from lumbar spine problems were examined using standard MRI protocols including an axial T2* mapping protocol. All discs were classified morphologically and grouped as "healthy" or "abnormal". Differences between groups were analysed regarding to the specific T2* pattern at different regions of interest (ROIs).Healthy intervertebral discs revealed a distinct cross-sectional T2* value profile: T2* values were significantly lower in the annulus fibrosus compared with the nucleus pulposus (P = 0.01). In abnormal IVDs, T2* values were significantly lower, especially towards the centre of the disc representing the expected decreased water content of the nucleus (P = 0.01). In herniated discs, ROIs within the nucleus pulposus and ROIs covering the annulus fibrosus showed decreased T2* values.Axial T2* mapping is effective to detect early stages of degenerative disc disease. There is a potential benefit of axial T2* mapping as a diagnostic tool, allowing the quantitative assessment of intervertebral disc degeneration.aEuro cent Axial T2* mapping effective in detecting early degenerative disc disease.aEuro cent Healthy and abnormal intervertebral discs revealed distinct cross-sectional T2* value profiles.aEuro cent T2* can be performed at 1.5 T in a clinical setting.