Burden of Orofacial Clefting in India, 2016: A Global Burden of Disease Approach.
Burden of Orofacial Clefting in India, 2016: A Global Burden of Disease Approach.
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DOI：
10.4103/ams.ams_196_17
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Balaji, S M
中科院分区：
文献类型：
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作者：
Balaji, S M
背景技术背景：在最近的过去，有不一致的报告，印度目睹了下降的趋势，口面裂（OFC）的发病率。迄今为止，几乎没有发表过全面的证据。为了确定流行病学参数方面的患病率、相关负担和估计“未满足”的OFC治疗需求，进行了本研究。使用2016年全球疾病负担方法及其假设，试图估计患病率，以量化印度OFC的负担，如残疾调整生命年（DALLS），寿命损失年（YLL），和年生活与残疾（YLD）以及死亡由于OFC。这种方法的结果。使用以前的估计“未满足”OFC治疗需求，试图估计目前的量“未满足”OFC治疗needs.RESULTS：在本研究中，据估计，共有0.033%的印度人口患有OFC。2016年，估计患病率/10万为男性33.27，女性31.01，男女合计32.18。据估计，在所有年龄段，每100 000名男性的死亡率为2.05，女性为2.66，男女均为2.34。OFC出生流行率模型显示，2016年在印度的比值比为0.48（1.56-1.65）和不记录的固定系数0.83（0.15-6.63），漏报0.97（0.88-1），性别1.09（1.02-1.16），染色体诊断1.22（1.22-1.22），死胎1.22（1.22-1.22）。总的未满足的唇腭裂治疗需求估计为79,430或18.76%的总印度唇腭裂人口OFC.CONCLUSIONS：内的数学建模的限制，并根据所有可用的调查，文献，和报告的数据，整体出生率和患病率的OFC在印度。在可靠的数据出现之前，目前的估计可以作为印度OFC患病率和负担的可靠估计。目前的企业强调需要精心设计，高质量的泛印度，以社区为基础的观察性研究，以准确估计印度OFC的负担。
BACKGROUND: In the recent past, there have been inconsistent reports of India witnessing a decreasing trend in the incidence of orofacial clefts (OFC). To date, little comprehensive evidence has been published. To identify the prevalence, associated burden in terms of epidemiological parameters and to estimate the "unmet" OFC treatment needs, the present study was undertaken.MATERIALS AND METHODS: Using the Global Burden of Diseases 2016 approach and its assumptions, an attempt was made to estimate the prevalence to quantify the burden of OFC in India as disability-adjusted life years (DALYs), years of life lost (YLL), and years lived with disability (YLD) as well as death due to OFC. The results from such an approach are presented. Using previous estimates of "unmet" OFC treatment needs, an attempt was made to estimate the current volume of "unmet" OFC treatment needs.RESULTS: In the present study, it was estimated that a total of 0.033% of all Indian population suffers from OFC. In 2016, the estimated prevalence rate/100,000 was 33.27 for males, 31.01 for females, and 32.18 combined for both genders. It was estimated that for all ages, the DALYs lost were 2.05 for 100,000 males, 2.66 for females and 2.34 for both sexes. The OFC birth prevalence model revealed that the birth prevalence (as a proportion) in 2016 in India showed an odds ratio of 0.48 (1.56-1.65) and fixed factor of nonrecording 0.83 (0.15-6.63), underreporting 0.97 (0.88-1), gender 1.09 (1.02-1.16), chromosomal diagnoses included 1.22 (1.22-1.22), and stillbirth 1.22 (1.22-1.22). The total unmet cleft treatment need was estimated at 79,430 or 18.76% of the total Indian cleft population with OFC.CONCLUSIONS: Within the constraints of the mathematical modeling and based on all available surveys, literature, and reported data, the overall birth prevalence and the prevalence of OFC in India are presented. Till reliable data emerges, the present estimates could serve as a robust estimate of the prevalence and burden of OFC in India. The present enterprise highlights the need for well-designed, high-quality Pan-India, community-based, observational studies to accurately estimate the burden of OFC in India.