Prognostic significance of entrapped liver cells in hepatic metastases from colorectal cancer
Prognostic significance of entrapped liver cells in hepatic metastases from colorectal cancer
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DOI：
10.1097/00000658-200011000-00006
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发表时间：
2000-11-01
影响因子：
9
通讯作者：
Kodama, S
中科院分区：
文献类型：
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作者：
Koike, M;Yasui, K;Kodama, S
目的将结直肠癌肝转移瘤中截留肝细胞的显微镜检查结果与肝切除术后的结果相关联。背景数据摘要：结直肠癌肝转移瘤切除后可靠的组织病理学预后因素尚未确定。方法根据显微镜观察到的频率，将 71 例因肝转移而接受根治性肝切除术的患者分为罕见组 (n = 36) 或频繁组 (n = 35)。结果肝切除术后的五年生存率，罕见组为 44.4%，常见组为 27.2%。使用Cox比例风险模型通过逐步方法进行的多变量分析将这种形态学变量确定为一个重要的独立预后因素。结论结直肠癌转移灶中发现的截留肝细胞反映了肿瘤的生物学活性，可能是一个有用的预后指标。
ObjectiveTo correlate the microscopic finding of entrapped liver cells in hepatic metastases from colorectal cancer with outcome after hepatectomy.Summary Background DataReliable histopathologic prognostic factors in resected liver metastases from colorectal cancer have not been identified.MethodsSeventy-one patients undergoing radical hepatectomy for liver metastases were assigned to rare (n = 36) or frequent (n = 35) groups according to the microscopically observed frequency of hepatocyte entrapment in the tumor.ResultsFive-year survival rates after hepatectomy were 44.4% for the rare group and 27.2% for the frequent group. Multivariate analysis using the Cox proportional hazards model by a stepwise method identified this morphologic variable as a significant independent prognostic factor.ConclusionsThe finding of entrapped liver cells in metastases from colorectal cancer reflects the biologic activity of the tumor and may be a useful prognostic indicator.