Effects of anaesthetics on guineapig tracheal smooth muscle.
Effects of anaesthetics on guineapig tracheal smooth muscle.
复制标题
麻醉剂对豚鼠气管平滑肌的影响。
DOI：
10.1093/bja/52.2.199
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发表时间：
1980
影响因子：
9.8
通讯作者：
M. Denborough
中科院分区：
文献类型：
--
作者：
F. Okumura;M. Denborough
静脉注射的影响体外研究了局麻药对豚鼠气管平滑肌的作用。地西泮、丙哌啶和氯胺酮可引起气管平滑肌松弛并拮抗组胺、乙酰胆碱和氯化钾引起的挛缩。麻醉剂的放松效果不受普萘洛尔的影响。临床使用浓度的硫喷妥钠引起气管平滑肌挛缩。吗啡可引起松弛并拮抗组胺引起的挛缩，但不能拮抗乙酰胆碱或氯化钾引起的挛缩。临床浓度的利多卡因和普鲁卡因可引起气管平滑肌挛缩。大剂量的利多卡因使气管肌肉放松，但大剂量的普鲁卡因会引起自发的节律性运动。利多卡因和普鲁卡因对抗组胺、乙酰胆碱和氯化钾引起的挛缩。
The effects of i.v. and local anaesthetics on guineapig tracheal smooth muscle have been investigated in vitro. Diazepam, propanidid and ketamine induced relaxation and antagonized histamine-, acetylcholine-and potassium chloride-induced contractures in the tracheal smooth muscle. The relaxing effects of the anaesthetics were not affected by propranolol. Thiopentone, at concentrations which would be used clinically, caused contracture of the tracheal smooth muscle. Morphine induced relaxation and antagonized histamine-induced contracture, but did not antagonize acetylcholine-or potassium chloride-induced contractures. Lignocaine and procaine, at clinical concentrations, induced contracture of tracheal smooth muscle. Large doses of lignocaine relaxed the tracheal muscle, but large doses of procaine induced spontaneous rhythmical movements. Lignocaine and procaine antagonized contractures induced by histamine, acetylcholine and potassium chloride.