Why do peroxisomes associate with the cytoskeleton?
Why do peroxisomes associate with the cytoskeleton?
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DOI：
10.1016/j.bbamcr.2015.11.022
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发表时间：
2016-05
期刊：
影响因子：
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通讯作者：
A. Neuhaus;C. Eggeling;R. Erdmann;W. Schliebs
中科院分区：
文献类型：
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作者：
A. Neuhaus;C. Eggeling;R. Erdmann;W. Schliebs
过氧化体与细胞骨架的连接以及沿微管细丝和肌动蛋白电缆的运动是代谢效率、生物发生、维持和遗传这一动态细胞间隔的重要和高度调控的过程。已鉴定出几种与过氧化物体相关的蛋白，它们介导与马达蛋白、接头蛋白或细胞骨架的其他成分的相互作用。似乎有一种特定物种的蛋白质-蛋白质相互作用的复杂性，需要控制定向移动和阻止。一个悬而未决的问题是，为什么一些在过氧化体蛋白输入中具有特定作用的蛋白质在调节细胞骨架结合和过氧化体的运动方面具有额外的功能。本文是由Ralf Erdmann编辑的题为：Peroxisome的特刊的一部分。
Attachment of peroxisomes to cytoskeleton and movement along microtubular filaments and actin cables are essential and highly regulated processes enabling metabolic efficiency, biogenesis, maintenance and inheritance of this dynamic cellular compartment. Several peroxisome-associated proteins have been identified, which mediate interaction with motor proteins, adaptor proteins or other constituents of the cytoskeleton. It appears that there is a species-specific complexity of protein–protein interactions required to control directional movement and arresting. An open question is why some proteins with a specific role in peroxisomal protein import have an additional function in the regulation of cytoskeleton binding and motility of peroxisomes. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann.