Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex
Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex
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DOI：
10.1016/s0304-3940(01)02239-x
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发表时间：
2001-11-02
影响因子：
2.5
通讯作者：
Siebner, HR
中科院分区：
文献类型：
--
作者：
Peinemann, A;Lehner, C;Siebner, HR
采用双相磁刺激，短刺激间隔（ISIs）双脉冲经颅磁刺激（TMS）研究皮层内抑制和促进平衡的年龄相关变化。对26名健康右撇子进行左主运动手区配对脉冲TMS后，记录了放松后的右第一背骨间肌的运动诱发电位。1-5 ms的皮质内配对脉冲抑制在老年人中显著降低，而11-15 ms的皮质内配对脉冲促进没有年龄效应。这一发现表明，正常的衰老与皮层内抑制回路的兴奋性相对降低有关。总之，配对脉冲经颅磁刺激提供了一种非侵入性的方法来研究运动皮层中与年龄相关的功能变化。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
Using biphasic magnetic stimuli, paired-pulse transcranial magnetic stimulation (TMS) at short interstimulus intervals (ISIs) was employed to investigate age-related changes in the balance between intracortical inhibition and facilitation. In 26 right-handed healthy individuals, motor evoked potentials were recorded from the relaxed right first dorsal interosseus muscle after paired-pulse TMS of the left primary motor hand area. The magnitude of intracortical paired-pulse inhibition at Isis of 1-5 ms was markedly reduced in elderly individuals, whereas no age effect was observed for intracortical paired-pulse facilitation at Isis of 11-15 ms. This finding demonstrates that normal aging is associated with a relative decrease in the excitability of intracortical inhibitory circuits. In conclusion, paired-pulse TMS provides a non-invasive means of studying age-related functional changes in the motor cortex. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.