Myocardial Mapping in Systemic Sarcoidosis: A Comparison of Two Measurement Approaches
Myocardial Mapping in Systemic Sarcoidosis: A Comparison of Two Measurement Approaches
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DOI：
10.1055/a-1174-0537
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发表时间：
2021-01-01
影响因子：
1.8
通讯作者：
Thomas, Daniel
中科院分区：
文献类型：
--
作者：
Dabir, Darius;Luetkens, Julian;Thomas, Daniel
目的探讨T1和T2标测能否区分系统性结节病患者的病变心肌和健康心肌，并比较标准标测方法(室中短轴切片的全心肌内测量)和更标准化的测定室间隔内松弛时间的方法(ConSept)。材料与方法24例经活检证实的心外结节病患者和17例健康对照受试者接受1.5T的CMR成像，包括自然T1和T2标测。将患者分为有(Lge+)和无(Lge-)心脏结节病两组。比较患者和对照组的T1和T2松弛时间。结果与使用SAX和ConSept方法的对照组相比，所有患者的T1和T2松弛时间均显著延长(p<；0.05)。然而，无论采用何种测量方法(ConSept/SAX)，LGE+和LGE-患者的T1和T2松弛时间没有显著差异(p>；0.05)。直接比较ConSept和SAXT1标测对健康心肌和病变心肌的鉴别符合率较高(Kappa=0.844)。结论T1和T2标测不仅可以无创性地识别系统性结节病患者的心脏受累，而且可以作为疾病早期心脏受累的标志物，以便及时治疗。结论与SAX方法相比，9月T1标测为该人群的组织定征提供了一种等同的方法。有必要进行进一步的研究，包括后续检查，以确认这些初步结果。
Purpose To investigate if T1 and T2 mapping is able to differentiate between diseased and healthy myocardium in patients with systemic sarcoidosis, and to compare the standard mapping measurement (measurement within the whole myocardium of the midventricular short axis slice, SAX) to a more standardized method measuring relaxation times within the midventricular septum (ConSept).Materials and Methods 24 patients with biopsy-proven extracardiac sarcoidosis and 17 healthy control subjects were prospectively enrolled in this study and underwent CMR imaging at 1.5T including native T1 and T2 mapping. Patients were divided into patients with (LGE+) and without (LGE-) cardiac sarcoidosis. T1 and T2 relaxation times were compared between patients and controls. Furthermore, the SAX and the ConSept approach were compared regarding differentiation between healthy and diseased myocardium.Results T1 and T2 relaxation times were significantly longer in all patients compared with controls using both the SAX and the ConSept approach (p < 0.05). However, LGE+ and LGE- patients showed no significant differences in T1 and T2 relaxation times regardless of the measurement approach used (ConSept/SAX) (p > 0.05). Direct comparison of ConSept and SAX T1 mapping showed high conformity in the discrimination between healthy and diseased myocardium (Kappa = 0.844).Conclusion T1 and T2 mapping may not only enable noninvasive recognition of cardiac involvement in patients with systemic sarcoidosis but may also serve as a marker for early cardiac involvement of the disease allowing for timely treat- ment. ConSept T1 mapping represents an equivalent method for tissue characterization in this population compared to the SAX approach. Further studies including follow-up examinations are necessary to confirm these preliminary results.