Iron Status Predicts Malaria Risk in Malawian Preschool Children
Iron Status Predicts Malaria Risk in Malawian Preschool Children
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DOI：
10.1371/journal.pone.0042670
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发表时间：
2012-08-16
期刊：
影响因子：
3.7
通讯作者：
Leenstra, Tjalling
中科院分区：
文献类型：
--
作者：
Jonker, Femkje A. M.;Calis, Job C. J.;Leenstra, Tjalling
简介：铁缺乏症在发展中国家的学龄前儿童中非常普遍，在撒哈拉以南非洲是一个重要的健康问题。关于缺铁对疟疾和其他感染的可能保护作用存在争议;但由于数据有限，缺乏共识。最近的研究集中在铁补充剂的风险，但个人的铁状况对疟疾风险的影响仍不清楚。在高感染负担地区的铁状况研究往往暴露于偏见。本研究的目的是评估基线铁状态对疟疾风险的预测价值，明确考虑潜在的偏倚。
Introduction: Iron deficiency is highly prevalent in pre-school children in developing countries and an important health problem in sub-Saharan Africa. A debate exists on the possible protective effect of iron deficiency against malaria and other infections; yet consensus is lacking due to limited data. Recent studies have focused on the risks of iron supplementation but the effect of an individual's iron status on malaria risk remains unclear. Studies of iron status in areas with a high burden of infections often are exposed to bias. The aim of this study was to assess the predictive value of baseline iron status for malaria risk explicitly taking potential biases into account.Methods and materials: We prospectively assessed the relationship between baseline iron deficiency (serum ferritin