THE EFFECT OF ZINC SUPPLEMENTATION ON PREGNANCY OUTCOME
THE EFFECT OF ZINC SUPPLEMENTATION ON PREGNANCY OUTCOME
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DOI：
10.1001/jama.274.6.463
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发表时间：
1995-08-09
影响因子：
120.7
通讯作者：
HAUTH, JC
中科院分区：
文献类型：
--
作者：
GOLDENBERG, RL;TAMURA, T;HAUTH, JC
目的：-评估怀孕期间补充锌是否与出生体重增加有关。设计-一项随机双盲安慰剂对照试验。设置-阿拉巴马大学伯明翰分校的门诊和分娩服务。患者-580名医学上贫穷但其他方面健康的非裔美国孕妇，她们在参加产前护理时血浆锌水平低于中位数，在怀孕19周时随机分组。根据人口体重指数中位数26公斤/米(2)，妇女被分成两组进行额外的分析。干预-服用不含锌的多种维生素/矿物质片剂的妇女被随机分成两组，每天服用25毫克锌或安慰剂直到分娩。主要观察指标：出生体重、出生时胎龄和出生时头围。结果：在所有妇女中，补锌组婴儿的出生体重(126克，P=0.03)和头围(0.4厘米，P=0.02)显著高于安慰剂组婴儿。在体重指数低于26公斤/米(2)的女性中，补充锌与婴儿出生体重增加248克(P=0.005)和婴儿头围增加0.7厘米(P=0.007)相关。补锌组的血浆锌浓度显著高于对照组。结论：在妊娠早期血浆锌浓度相对较低的妇女中，每日补锌与婴儿出生体重和头围增加有关，这种影响主要发生在体重指数低于26 kg/m(2)的妇女。
Objective.-To evaluate whether zinc supplementation during pregnancy is associated with an increase in birth weight.Design.-A randomized double-blind placebo-controlled trial.Setting.-Outpatient clinic and delivery service at the University of Alabama at Birmingham.Patients.-Five hundred eighty medically indigent but otherwise healthy African-American pregnant women with plasma zinc levels below the median at enrollment in prenatal care, randomized at 19 weeks' gestational age. Women were subdivided by the population median body mass index of 26 kg/m(2) into two groups for additional analyses.Intervention.-Women who were taking a non-zinc-containing prenatal multivitamin/mineral tablet were randomized to receive either a daily dose of 25 mg of zinc or a placebo until delivery.Main Outcome Measures.-Birth weight, gestational age at birth, and head circumference at birth.Results.-In all women, infants in the zinc supplement group had a significantly greater birth weight (126 g, P=.03) and head circumference (0.4 cm, P=.02) than infants in the placebo group. In women with a body mass index less than 26 kg/m(2), zinc supplementation was associated with a 248-g higher infant birth weight (P=.005) and a 0.7-cm larger infant head circumference (P=.007). Plasma zinc concentrations were significantly higher in the zinc supplement group.Conclusions.-Daily zinc supplementation in women with relatively low plasma zinc concentrations in early pregnancy is associated with greater infant birth weights and head circumferences, with the effect occurring predominantly in women with a body mass index less than 26 kg/m(2).