Fatality due to gamma-hydroxybutyric acid (GHB) and heroin intoxication.
Fatality due to gamma-hydroxybutyric acid (GHB) and heroin intoxication.
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因 γ-羟基丁酸 (GHB) 和海洛因中毒而死亡。
DOI：
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发表时间：
1995
影响因子：
1.6
通讯作者：
Alessandra Rossi
中科院分区：
文献类型：
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作者：
S. Ferrara;L. Tedeschi;G. Frison;Alessandra Rossi
报告了第一例由于摄入γ-羟丁酸和静脉注射海洛因而导致的致命中毒。一名42岁的男子被发现死亡，他被认为是海洛因成瘾者，并服用其他精神活性物质，已接受伽马--羟丁酸治疗数月。解剖组织病理学检查显示全身内脏充血、水肿及肺炭疽病、慢性支气管炎和慢性活动性肝炎。毒理学结果包括伽马-羟丁酸、吗啡和6-单乙酰吗啡在体液和组织中的分布。GHB和吗啡的浓度分别为11.5和0.77微克/毫升（血液），84.3和0.3微克/毫升（玻璃体液），258.3和1.35微克/毫升（尿液），57.0和14.3微克/毫升（胆汁），40.0和0.43微克/克（脑），43.0和0.60微克/克（肝脏），47.0和0.68微克/克（肾脏）。血和尿中6-单乙酰吗啡浓度分别为28.5和12.1 ng/mL。假定的作用机制和GHB的药代动力学进行了简要审查，参考其治疗用途和非致命GHB中毒的报告。
The first case of fatal intoxication due to ingestion of gamma-hydroxybutyric acid (GHB) and intravenous use of heroin is reported. A 42-year-old man, known to have been a heroin addict and to have taken other psychoactive substances, who had been in treatment with GHB for several months, was found dead. Anatomohistopathologic examination showed generalized visceral congestion, edema and pulmonary anthracosis, chronic bronchitis and chronic active hepatitis. Toxicological findings included fluid and tissue distributions of GHB, morphine and 6-monoacetylmorphine. GHB and morphine concentrations were respectively 11.5 and 0.77 micrograms/mL (blood), 84.3 and 0.3 micrograms/mL (vitreous humor), 258.3 and 1.35 micrograms/mL (urine), 57.0 and 14.3 micrograms/mL (bile), 40.0 and 0.43 micrograms/g (brain), 43.0 and 0.60 micrograms/g (liver), 47.0 and 0.68 micrograms/g (kidney). Blood and urine levels of 6-monoacetylmorphine were 28.5 and 12.1 ng/mL respectively. The presumed mechanism of action and pharmacokinetics of GHB are briefly reviewed, with reference to its therapeutic use and to reports of non-fatal GHB intoxication.