Geometric and dosimetric accuracy of deformable image registration between average-intensity images for 4DCT-based adaptive radiotherapy for non-small cell lung cancer.
Geometric and dosimetric accuracy of deformable image registration between average-intensity images for 4DCT-based adaptive radiotherapy for non-small cell lung cancer.
复制标题
DOI：
10.1002/acm2.13341
复制
发表时间：
2021-08
影响因子：
2.1
通讯作者：
Brock K
中科院分区：
文献类型：
--
作者：
He Y;Cazoulat G;Wu C;Peterson C;McCulloch M;Anderson B;Pollard-Larkin J;Balter P;Liao Z;Mohan R;Brock K
基于四维计算机断层扫描（4DCT）的肺部自适应放射治疗的重新规划通常需要在计划平均强度图像（AVG）和新获取的AVG之间进行变形剂量映射。然而，这种AVG - AVG变形图像配准（DIR）缺乏准确性评估。当前的工作对AVG - AVG DIR和相应的相位 - 相位DIR的几何精度进行了量化和比较，并随后研究了这种AVG - AVG DIR对变形剂量映射的临床影响。
在28例非小细胞肺癌患者的计划4DCT和治疗中期4DCT之间进行了基于混合强度的AVG - AVG和相位 - 相位DIR。一种自动标志点识别算法检测了双肺的血管分叉对。计算了这两种DIR类型下这些标志点对的目标配准误差（TRE）。分析了计划4DCT中TRE与呼吸诱导的标志点运动之间的相关性。使用全局和局部剂量指标来评估两种DIR类型下AVG - AVG变形剂量映射的临床意义。
AVG - AVG和相位 - 相位DIR的TRE分别平均为3.2±1.0毫米和2.6±0.8毫米（p < 0.001）。使用AVG - AVG DIR时，运动<10毫米的标志点的TRE平均为2.9±2.0毫米，而其余标志点为3.1±1.9毫米（p < 0.01）。相比之下，相位 - 相位DIR未显示出显著差异。在剂量学方面，使用AVG - AVG DIR和相位 - 相位DIR映射的剂量在全局剂量指标上未观察到显著差异，但AVG - AVG DIR的TRE与局部剂量差异之间存在正线性关系（p = 0.04）。
当感兴趣区域经历<10毫米的呼吸诱导运动时，AVG - AVG DIR可能提供足够的几何精度；相反，则需要格外注意，并建议使用相位 - 相位DIR。在剂量学方面，AVG - AVG和相位 - 相位DIR之间几何精度的差异并未影响基于肺部的全局指标。然而，由于毒性评估需要更局部的剂量指标，可能需要相位 - 相位DIR，因为其较低的平均TRE改善了基于体素的剂量测定。
Re‐planning for four‐dimensional computed tomography (4DCT)‐based lung adaptive radiotherapy commonly requires deformable dose mapping between the planning average‐intensity image (AVG) and the newly acquired AVG. However, such AVG‐AVG deformable image registration (DIR) lacks accuracy assessment. The current work quantified and compared geometric accuracies of AVG‐AVG DIR and corresponding phase‐phase DIRs, and subsequently investigated the clinical impact of such AVG‐AVG DIR on deformable dose mapping. Hybrid intensity‐based AVG‐AVG and phase‐phase DIRs were performed between the planning and mid‐treatment 4DCTs of 28 non‐small cell lung cancer patients. An automated landmark identification algorithm detected vessel bifurcation pairs in both lungs. Target registration error (TRE) of these landmark pairs was calculated for both DIR types. The correlation between TRE and respiratory‐induced landmark motion in the planning 4DCT was analyzed. Global and local dose metrics were used to assess the clinical implications of AVG‐AVG deformable dose mapping with both DIR types. TRE of AVG‐AVG and phase‐phase DIRs averaged 3.2 ± 1.0 and 2.6 ± 0.8 mm respectively (p < 0.001). Using AVG‐AVG DIR, TREs for landmarks with <10 mm motion averaged 2.9 ± 2.0 mm, compared to 3.1 ± 1.9 mm for the remaining landmarks (p < 0.01). Comparatively, no significant difference was demonstrated for phase‐phase DIRs. Dosimetrically, no significant difference in global dose metrics was observed between doses mapped with AVG‐AVG DIR and the phase‐phase DIR, but a positive linear relationship existed (p = 0.04) between the TRE of AVG‐AVG DIR and local dose difference. When the region of interest experiences <10 mm respiratory‐induced motion, AVG‐AVG DIR may provide sufficient geometric accuracy; conversely, extra attention is warranted, and phase‐phase DIR is recommended. Dosimetrically, the differences in geometric accuracy between AVG‐AVG and phase‐phase DIRs did not impact global lung‐based metrics. However, as more localized dose metrics are needed for toxicity assessment, phase‐phase DIR may be required as its lower mean TRE improved voxel‐based dosimetry.
登录
查看更多内容
影响因子：
3.8
作者：
Samavati, Navid;Velec, Michael;Brock, Kristy K.
通讯作者：
Brock, Kristy K.
影响因子：
3.8
作者：
Glide-Hurst, Carri K.;Hugo, Geoffrey D.;Yan, Di
通讯作者：
Yan, Di
DOI：
10.1016/j.ijrobp.2004.06.021
发表时间：
2004-11-01
影响因子：
7
作者：
Mageras, GS;Pevsner, A;Ling, CC
通讯作者：
Ling, CC
影响因子：
3.8
作者：
Brock, Kristy K.;Mutic, Sasa;Kessler, Marc L.
通讯作者：
Kessler, Marc L.
DOI：
10.1007/s13246-014-0262-0
发表时间：
2014-06-01
影响因子：
--
作者：
Hardcastle, Nicholas;Bender, Edward T.;Tome, Wolfgang A.
通讯作者：
Tome, Wolfgang A.