URINARY-EXCRETION OF ACETYLCARNITINE DURING HUMAN DIABETIC AND FASTING KETOSIS
URINARY-EXCRETION OF ACETYLCARNITINE DURING HUMAN DIABETIC AND FASTING KETOSIS
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DOI：
10.1152/ajpendo.1982.243.2.e168
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
GENUTH, SM
中科院分区：
文献类型：
--
作者：
HOPPEL, CL;GENUTH, SM
研究了糖尿病酮症患者在胰岛素治疗前和治疗期间以及正常体重和肥胖受试者空腹时的尿乙酰卡尼汀排泄。在糖尿病酮病患者中，乙酰肉毒碱占总乙酰肉毒碱排泄量的61%。在第一个24小时的胰岛素治疗，乙酰肉毒碱排泄减少，并在治疗的第5天是18%的酰基肉毒碱排泄。其他酰基肉毒碱的尿排泄量下降缓慢。在正常体重的受试者禁食3天，尿中排泄的乙酰肉碱增加的第2天的禁食，并在第3天的乙酰肉碱占78%的排泄的酰基肉碱。在肥胖的受试者有一个渐进的增加尿中的乙酰肉毒碱排泄，但在第6天，它只占55%的总酰基肉毒碱排泄。乙酰肉毒碱的尿排泄与血液β-肾上腺素相关。正常体重受试者在禁食期间和糖尿病酮症患者中的羟基丁酸盐浓度。乙酰肉毒碱占在研究的3种酮症条件下排泄的酰基肉毒碱的主要部分。乙酰肉毒碱的贡献，酰基肉毒碱的变化，酮症的出现或消失是显着低于在肥胖的主题比在正常体重的主题或糖尿病患者。这种差异可能反映了肥胖症中乙酰辅酶A和乙酰肉碱的产生或处置的改变。[肉毒碱是脂肪酸氧化的重要因素。]。
The urinary excretion of acetylcarnitine was studied in patients with diabetic ketosis before and during insulin therapy and in normal-weight and obese subjects during fasting. In the diabetic ketotic patients, acetylcarnitine represented 61% of the total acylcarnitine excretion. During the first 24 h of insulin treatment, acetylcarnitine excretion decreased and on the 5th day of treatment was 18% of the acylcarnitines excreted. The urinary excretion of the other acylcarnitines fell slowly. In normal-weight subjects fasted for 3 days, the urinary excretion of acetylcarnitine increased on the 2nd day of fasting, and on the 3rd day acetylcarnitine accounted for 78% of the excreted acylcarnitine. In obese subjects there was a progressive increase in urinary acetylcarnitine excretion, but on day 6 it represented only 55% of the total acylcarnitine excreted. The urinary excretion of acetylcarnitine correlated with blood .beta.-hydroxybutyrate concentration in the normal-weight subjects during fasting and in the diabetic ketotic patients. Acetylcarnitine accounts for a major fraction of the acylcarnitines excreted in the 3 ketotic conditions studied. The contribution of acetylcarnitine to the change in acylcarnitines as ketosis appears or disappears is significantly less in the obese subjects than in the normal-weight subjects or in the diabetic patients. This difference may reflect an alteration in the production or disposition of acetyl-CoA and acetylcarnitine in obesity. [Carnitine is an essential factor in fatty acid oxidation.].