Clinicopathological evaluation of radiation induced basal cell carcinoma.
Clinicopathological evaluation of radiation induced basal cell carcinoma.
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DOI：
10.4103/0019-5154.43222
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发表时间：
2008-01-01
影响因子：
1.7
通讯作者：
Nahidi, Yalda
中科院分区：
文献类型：
--
作者：
Meibodi, Naser Tayyebi;Maleki, Masood;Nahidi, Yalda
背景：皮肤肿瘤的发展是放射治疗最重要的慢性并发症之一。基底细胞癌 (BCC) 是发生在接受放射治疗的身体区域最常见的癌症。 目的：本研究的目的是评估有放射治疗史的患者基底细胞癌的临床和组织学方面。 材料和方法：回顾了伊朗伊玛目礼萨医院病理科 80 名接受放射治疗的基底细胞癌患者 (1996-2006) 的医疗记录和显微镜切片。伊朗马什哈德。采用描述性检验对收集的数据进行统计分析。结果：纳入60名男性和20名女性，其中大多数年龄在60多岁。斑块是基底细胞癌最常见的临床模式。 51% 的患者有色素沉着，42.5% 的患者有多个病变。头皮是最常见的受累部位。组织学上，大结节癌和色素沉着癌是基底细胞癌最主要的形式。讨论：大多数患者有头皮受累和多发性病变。结节状和色素沉着形式是最常见的组织学发现。我们建议需要对过去有放射治疗史的患者进行密切监督。
BACKGROUND: Development of skin neoplasms is one of the most important chronic complications of radiation therapy. Basal cell carcinoma (BCC) is the most frequent carcinoma occurring at the region of the body to which radiotherapy was delivered.AIM: The aim of this study was to evaluate clinical and histological aspects of basal cell carcinoma in patients with a history of radiotherapy.MATERIALS AND METHODS: Medical records and microscopic slides of 80 patients with basal cell carcinoma who had received radiotherapy (1996-2006) were reviewed in pathology department of Imam Reza hospital of Mashhad, Iran. Collected data were analyzed statistically using descriptive test.RESULTS: 60 men and 20 women were included, majority of them in their sixties. Plaque was the most common clinical pattern of basal cell carcinoma. Fifty one percent of the patients had pigmented and 42.5% had multiple lesions. Scalp was the most common site of involvement. Histologically, macronodular and pigmented carcinoma were the most predominant forms of basal cell carcinoma.DISCUSSION: Majority of patients had scalp involvement and multiple lesions. Nodular and pigmented forms were the most common histological findings. We suggest the need for close supervision in patients with a history of radio therapy in the past.