Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.
Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.
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DOI：
10.1021/ja2033734
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发表时间：
2011-08-17
影响因子：
15
通讯作者：
Burgess K
中科院分区：
文献类型：
--
作者：
Raghuraman A;Ko E;Perez LM;Ioerger TR;Burgess K
肽模拟物1 - 3由氨基酸衍生的特特拉姆酸7作为关键起始材料制备。计算表明，1的优选构象比3更有效地将其侧链载体与常见二级结构中的氨基酸对齐。发现2（1的扩展衍生物）的优选构象与片-转-片基序非常吻合。
Peptidomimetics 1 – 3 were prepared from aminoacid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet-turn-sheet motif.