Regulation of macrophage-derived chemokine (MDC, CCL22) production.
Regulation of macrophage-derived chemokine (MDC, CCL22) production.
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DOI：
10.1615/critrevimmunol.v22.i2.10
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发表时间：
2002
影响因子：
1.3
通讯作者：
U. Yamashita;E. Kuroda
中科院分区：
文献类型：
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作者：
U. Yamashita;E. Kuroda
巨噬细胞源性趋化因子（MDC，CCL 22）是CC-趋化因子家族的成员，由69个氨基酸残基组成。MDC主要由巨噬细胞和树突状细胞在微生物制品或抗CD 40抗体刺激下产生，并且被TH 2型细胞因子如IL-4和IL-5上调，但被TH 1型细胞因子如IFN-γ下调。MDC的产生也被前列腺素和环AMP升高剂上调。MDC引起树突状细胞和TH 2细胞的趋化性迁移。此外，MDC在TH 2相关疾病的病变中高度表达，如气道过敏和特应性皮炎。因此，MDC在将TH 2细胞募集到炎症部位和调节TH 2相关免疫应答中起重要作用。
Macrophage-derived chemokine (MDC, CCL22) is a member of the CC-chemokine family and is composed of 69 amino acid residues. MDC is mainly produced by macrophages and dendritic cells upon the stimulation with microbial products, or anti-CD40 antibody, and is upregulated by TH2-type cytokines, such as IL-4 and -5, but is downregulated by TH1-type cytokines, such as IFN-gamma. MDC-production is also upregulated by prostaglandin and cyclic AMP-elevating agents. MDC causes chemotactic migration of dendritic cells and TH2 cells. Furthermore, MDC is highly-expressed in the lesions of TH2-related diseases, such as airway hypersensitivity and atopic dermatitis. Thus, MDC plays an important role in the recruitment of TH2 cells into the inflammatory sites and the regulation of TH2-related immune responses.